Astrocyte-derived TNF and glutamate critically modulate microglia activation by methamphetamine

T Canedo, CC Portugal, R Socodato… - …, 2021 - nature.com
Methamphetamine (Meth) is a powerful illicit psychostimulant, widely used for recreational
purposes. Besides disrupting the monoaminergic system and promoting oxidative brain …

Dental pulp stem cell-derived secretome and its regenerative potential

JK Bar, A Lis-Nawara, PG Grelewski - International Journal of Molecular …, 2021 - mdpi.com
The therapeutic potential of the dental pulp stem (DSC) cell-derived secretome, consisting of
various biomolecules, is undergoing intense research. Despite promising in vitro and in vivo …

Myelin in Alzheimer's disease: culprit or bystander?

M Maitre, H Jeltsch-David, NG Okechukwu… - Acta Neuropathologica …, 2023 - Springer
Alzheimer's disease (AD) is a neurodegenerative disorder with neuronal and synaptic
losses due to the accumulation of toxic amyloid β (Αβ) peptide oligomers, plaques, and …

On the neuroprotective effects of naringenin: pharmacological targets, signaling pathways, molecular mechanisms, and clinical perspective

Z Nouri, S Fakhri, FF El-Senduny, N Sanadgol… - Biomolecules, 2019 - mdpi.com
As a group of progressive, chronic, and disabling disorders, neurodegenerative diseases
(NDs) affect millions of people worldwide, and are on the rise. NDs are known as the …

Climate change and neurodegenerative diseases

P Bongioanni, R Del Carratore, S Corbianco… - Environmental …, 2021 - Elsevier
The climate change induced global warming, and in particular the increased frequency and
intensity of heat waves, have been linked to health problems. Among them, scientific works …

[HTML][HTML] AAV targeting of glial cell types in the central and peripheral nervous system and relevance to human gene therapy

SJ O'Carroll, WH Cook, D Young - Frontiers in Molecular …, 2021 - frontiersin.org
Different glial cell types are found throughout the central (CNS) and peripheral nervous
system (PNS), where they have important functions. These cell types are also involved in …

[HTML][HTML] Stem cell-derived extracellular vesicles as new tools in regenerative medicine-immunomodulatory role and future perspectives

E Karnas, P Dudek, EK Zuba-Surma - Frontiers in immunology, 2023 - frontiersin.org
In the last few decades, the practical use of stem cells (SCs) in the clinic has attracted
significant attention in the regenerative medicine due to the ability of these cells to proliferate …

SIRT1 activation by 2, 3, 5, 6-tetramethylpyrazine alleviates neuroinflammation via inhibiting M1 microglia polarization

Y Chen, F Peng, C Yang, H Hou, Z Xing… - Frontiers in …, 2023 - frontiersin.org
Background Neuroinflammation has been reported as a potential contributing factor to brain
diseases, and is characterized by activated microglia with release of multiple inflammatory …

[HTML][HTML] Efficacy and safety of probiotics for the treatment of Alzheimer's disease, mild cognitive impairment, and Parkinson's Disease: a systematic review and meta …

S Xiang, JL Ji, S Li, XP Cao, W Xu, L Tan… - Frontiers in aging …, 2022 - frontiersin.org
Background: Alzheimer's disease (AD) and Parkinson's disease (PD) are two of the most
common neurodegenerative diseases, and mild cognitive impairment (MCI) is considered a …

Postmortem evidence of brain inflammatory markers in bipolar disorder: a systematic review

VV Giridharan, P Sayana, OF Pinjari, N Ahmad… - Molecular …, 2020 - nature.com
Bipolar disorder (BD) is a chronic affective disorder with extreme mood swings that include
mania or hypomania and depression. Though the exact mechanism of BD is unknown …