Chronic pain is a serious public health problem with a strong affective-motivational
component that makes it difficult to treat. Most patients with chronic pain suffer from severe …

Cellular senescence is a critical part of human anti-tumor defence; however, the
accumulation of senescent cells with age underpins a wide range of pathologies. Senescent …

Abstract Protein phosphatase 2A (PP2A) is a highly complex heterotrimeric enzyme that
catalyzes the selective removal of phosphate groups from protein serine and threonine …

First seen as a fat-storage tissue, the adipose tissue is considered as a critical player in the
endocrine system. Precisely, adipose tissue can produce an array of bioactive factors …

Aging-related neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's
disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), are …

Chronic inflammation of the central nervous system (CNS), termed neuroinflammation, is a
hallmark of aging and a proposed mediator of cognitive decline associated with aging …

Alzheimer's disease (AD) is the most common form of dementia that remains incurable and
has become a major medical, social, and economic challenge worldwide. AD is …

With the advent of an aging society, the incidence of dementia is increasing, resulting in a
vast burden on society. It is increasingly acknowledged that neuroinflammation is implicated …

Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders. The
etiology and pathology of AD are complicated, variable, and yet to be completely …

Alzheimer's disease (AD) is marked by the presence of amyloid beta (Aβ) plaques,
neurofibrillary tangles (NFT), neuronal death and synaptic loss, and inflammation in the …