Mangiferin: A multipotent natural product preventing neurodegeneration in Alzheimer's and Parkinson's disease models

ST Feng, ZZ Wang, YH Yuan, HM Sun, NH Chen… - Pharmacological …, 2019 - Elsevier
Alzheimer's disease (AD) and Parkinson's disease (PD) are recognized as the universal
neurodegenerative diseases, with the involvement of misfolded proteins pathology, leading …

[HTML][HTML] Targeting NLRP3 inflammasome in the treatment of CNS diseases

BZ Shao, Q Cao, C Liu - Frontiers in molecular neuroscience, 2018 - frontiersin.org
Central nervous system (CNS) is one of the largest killers of people's health all over the
world. The overactivation of the immune and inflammatory responses is considered as an …

The role of mitochondrial damage‐associated molecular patterns in chronic neuroinflammation

E Bajwa, CB Pointer, A Klegeris - Mediators of inflammation, 2019 - Wiley Online Library
Mitochondrial dysfunction has been established as a common feature of neurodegenerative
disorders that contributes to disease pathology by causing impaired cellular energy …

[HTML][HTML] Auranofin mediates mitochondrial dysregulation and inflammatory cell death in human retinal pigment epithelial cells: implications of retinal …

T Yumnamcha, TS Devi, LP Singh - Frontiers in Neuroscience, 2019 - frontiersin.org
Purpose Photoreceptor degeneration occurs in various retinal diseases including age-
related macular degeneration (AMD), Retinitis pigmentosa (RP), and diabetic retinopathy …

[HTML][HTML] Anti-inflammatory and neuroprotective agents in clinical trials for CNS disease and injury: where do we go from here?

K Mallah, C Couch, DM Borucki, A Toutonji… - Frontiers in …, 2020 - frontiersin.org
Neurological disorders are major contributors to death and disability worldwide. The
pathology of injuries and disease processes includes a cascade of events that often involve …

[HTML][HTML] Microbial BMAA and the pathway for Parkinson's disease neurodegeneration

D Nunes-Costa, JD Magalhães… - Frontiers in Aging …, 2020 - frontiersin.org
The neurotoxin β-N-methylamino-L-alanine (BMAA) is a natural non-proteinogenic diamino
acid produced by several species of both prokaryotic (cyanobacteria) and eukaryotic …

[HTML][HTML] The role of the ZEB1–neuroinflammation axis in CNS disorders

E Poonaki, UD Kahlert, SG Meuth, A Gorji - Journal of Neuroinflammation, 2022 - Springer
Zinc finger E-box binding homeobox 1 (ZEB1) is a master modulator of the epithelial–
mesenchymal transition (EMT), a process whereby epithelial cells undergo a series of …

Gut microbiome interventions in human health and diseases

P Nie, Z Li, Y Wang, Y Zhang, M Zhao… - Medicinal research …, 2019 - Wiley Online Library
Ongoing studies have determined that the gut microbiota is a major factor influencing both
health and disease. Host genetic factors and environmental factors contribute to differences …

[HTML][HTML] Electroacupuncture alleviates ischemic brain injury by inhibiting the miR-223/NLRP3 pathway

R Sha, B Zhang, X Han, J Peng, C Zheng… - … medical journal of …, 2019 - ncbi.nlm.nih.gov
Background Electroacupuncture (EA) has been commonly used to treat stroke in China.
However, the underlying mechanism remains largely unknown. The present study …

Rational Design and Acoustic Assembly of Human Cerebral Cortex‐Like Microtissues from hiPSC‐Derived Neural Progenitors and Neurons

J Wang, H Qiao, Z Wang, W Zhao, T Chen… - Advanced …, 2023 - Wiley Online Library
Abstract Development of biologically relevant and clinically relevant human cerebral cortex
models is demanded by mechanistic studies of human cerebral cortex‐associated …