The blood–brain barrier: structure, regulation, and drug delivery

D Wu, Q Chen, X Chen, F Han, Z Chen… - Signal Transduction and …, 2023 - nature.com
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …

Spontaneous subarachnoid haemorrhage

J Claassen, S Park - The Lancet, 2022 - thelancet.com
Subarachnoid haemorrhage (SAH) is the third most common subtype of stroke. Incidence
has decreased over past decades, possibly in part related to lifestyle changes such as …

Mechanisms of blood–brain barrier protection by microbiota-derived short-chain fatty acids

E Fock, R Parnova - Cells, 2023 - mdpi.com
Impairment of the blood–brain barrier (BBB) integrity is implicated in the numerous
neurological disorders associated with neuroinflammation, neurodegeneration and aging. It …

[HTML][HTML] A novel mechanism linking ferroptosis and endoplasmic reticulum stress via the circPtpn14/miR-351-5p/5-LOX signaling in melatonin-mediated treatment of …

C Wu, M Du, R Yu, Y Cheng, B Wu, J Fu, W Tan… - Free Radical Biology …, 2022 - Elsevier
Traumatic brain injury (TBI) can lead to disability or devastating consequences with few
established treatments. Although ferroptosis has been shown to be involved in TBI, the …

Novel targets, treatments, and advanced models for intracerebral haemorrhage

M Zille, TD Farr, RF Keep, C Römer, G Xi, J Boltze - EBioMedicine, 2022 - thelancet.com
Intracerebral haemorrhage (ICH) is the second most common type of stroke and a major
cause of mortality and disability worldwide. Despite advances in surgical interventions and …

White matter injury in infants with intraventricular haemorrhage: mechanisms and therapies

P Ballabh, LS de Vries - Nature Reviews Neurology, 2021 - nature.com
Intraventricular haemorrhage (IVH) continues to be a major complication of prematurity that
can result in cerebral palsy and cognitive impairment in survivors. No optimal therapy exists …

[HTML][HTML] Brain edema formation and therapy after intracerebral hemorrhage

Y Wan, KG Holste, Y Hua, RF Keep, G Xi - Neurobiology of disease, 2023 - Elsevier
Intracerebral hemorrhage (ICH) accounts for about 10% of all strokes in the United States of
America causing a high degree of disability and mortality. There is initial (primary) brain …

[HTML][HTML] An MMP-9 exclusive neutralizing antibody attenuates blood-brain barrier breakdown in mice with stroke and reduces stroke patient-derived MMP-9 activity

Y Ji, Q Gao, Y Ma, F Wang, X Tan, D Song… - Pharmacological …, 2023 - Elsevier
Rapid upregulation of matrix metalloproteinase 9 (MMP-9) leads to blood-brain barrier
(BBB) breakdown following stroke, but no MMP-9 inhibitors have been approved in clinic …

Emerging roles of astrocytes in blood-brain barrier disruption upon amyloid-beta insults in Alzheimer's disease

Q Yue, MPM Hoi - Neural Regeneration Research, 2023 - journals.lww.com
Blood-brain barrier disruption occurs in the early stages of Alzheimer's disease. Recent
studies indicate a link between blood-brain barrier dysfunction and cognitive decline and …

[HTML][HTML] Hemorrhagic and ischemic stroke in patients with coronavirus disease 2019: incidence, risk factors, and pathogenesis-a systematic review and meta-analysis

S Syahrul, HA Maliga, M Ilmawan, M Fahriani… - …, 2021 - ncbi.nlm.nih.gov
Background: In this study, we aimed to determine the global prevalence, chronological order
of symptom appearance, and mortality rates with regard to hemorrhagic and ischemic stroke …