Nonalcoholic fatty liver disease (NAFLD) has reached epidemic proportions worldwide.
NAFLD and type 2 diabetes mellitus (T2DM) are known to frequently coexist and act …

The bioactive sphingolipid metabolites ceramide and sphingosine-1-phosphate (S1P) are a
recent addition to the lipids accumulated in obesity and have emerged as important …

The global prevalence of metabolic diseases such as type 2 diabetes mellitus,
steatohepatitis, myocardial infarction, and stroke has increased dramatically over the past …

Ceramides contribute to the lipotoxicity that underlies diabetes, hepatic steatosis, and heart
disease. By genetically engineering mice, we deleted the enzyme dihydroceramide …

Abstract Hypoxia-inducible factors (HIFs), a family of transcription factors activated by
hypoxia, consist of three α-subunits (HIF1α, HIF2α and HIF3α) and one β-subunit (HIF1β) …

OBJECTIVE Nonalcoholic fatty liver disease (ie, increased intrahepatic triglyceride [IHTG]
content), predisposes to type 2 diabetes and cardiovascular disease. Adipose tissue …

Adipose tissue possesses the remarkable capacity to control its size and function in
response to a variety of internal and external cues, such as nutritional status and …

In recent months, Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the world. COVID-19 …

Ceramides are products of metabolism that accumulate in individuals with obesity or
dyslipidaemia and alter cellular processes in response to fuel surplus. Their actions, when …

BACKGROUND Ceramides are sphingolipids that play causative roles in diabetes and heart
disease, with their serum levels measured clinically as biomarkers of cardiovascular disease …