Acute bed rest places older adults at risk for health complications by disrupting homeostasis
in many organ systems, including the cardiovascular system. Circulating ceramides are …

Obesity leads to persistent increases in immune responses that contribute to
cardiometabolic pathologies such as diabetes and cardiovascular disease. Pro …

The de novo ceramide synthesis pathway is essential to human biology and health, but
genetic influences remain unexplored. The core function of this pathway is the generation of …

Atherosclerosis is the deposition of plaque in the main arteries. It is an inflammatory
condition involving the accumulation of macrophages and various lipids (low-density …

Background Individuals with long standing diabetes duration can experience damage to
small microvascular blood vessels leading to diabetes complications (DCs) and increased …

Sphingolipids have been implicated in the etiology of atherosclerosis. The commonly used
sphingolipid inhibitors, myriocin (a ceramide inhibitor) and d-PDMP (d-threo-1-phenyl-2 …

Cardiometabolic diseases (CMD) represent a growing socioeconomic burden and concern
for healthcare systems worldwide. Improving patients' metabolic phenotyping in clinical …

Background Ceramides are a novel biomarker for numerous obesity-associated disorders
such as type II diabetes mellitus (T2D) and atherosclerosis. Ceramides were considered as …

Sphingolipids are ubiquitous components of eukaryotic cell membranes and have been
widely studied over the past couple of decades due to the discovery of their involvement in a …

Cardiovascular disease poses a significant threat to the quality of human life. Metabolic
abnormalities caused by excessive caloric intake have been shown to lead to the …