Long Covid: where we stand and challenges ahead

A Mantovani, MC Morrone, C Patrono… - Cell Death & …, 2022 - nature.com
Post-acute sequelae of SARS-CoV-2 (PASC), also known as Post-Covid Syndrome, and
colloquially as Long Covid, has been defined as a constellation of signs and symptoms …

Post-acute sequelae of COVID-19: understanding and addressing the burden of multisystem manifestations

M Parotto, M Gyöngyösi, K Howe, SN Myatra… - The Lancet …, 2023 - thelancet.com
Individuals with SARS-CoV-2 infection can develop symptoms that persist well beyond the
acute phase of COVID-19 or emerge after the acute phase, lasting for weeks or months after …

[HTML][HTML] Muscle abnormalities worsen after post-exertional malaise in long COVID

B Appelman, BT Charlton, RP Goulding… - Nature …, 2024 - nature.com
A subgroup of patients infected with SARS-CoV-2 remain symptomatic over three months
after infection. A distinctive symptom of patients with long COVID is post-exertional malaise …

Myopathy as a cause of fatigue in long‐term post‐COVID‐19 symptoms: Evidence of skeletal muscle histopathology

EK Hejbøl, T Harbo, J Agergaard… - European Journal of …, 2022 - Wiley Online Library
Background and purpose Among post‐COVID‐19 symptoms, fatigue is reported as one of
the most common, even after mild acute infection, and as the cause of fatigue, myopathy …

A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications

DB Kell, GJ Laubscher, E Pretorius - Biochemical Journal, 2022 - portlandpress.com
Post-acute sequelae of COVID (PASC), usually referred to as 'Long COVID'(a phenotype of
COVID-19), is a relatively frequent consequence of SARS-CoV-2 infection, in which …

WHO working definition of vitality capacity for healthy longevity monitoring

I Bautmans, V Knoop, JA Thiyagarajan… - The Lancet Healthy …, 2022 - thelancet.com
Intrinsic capacity, a crucial concept in healthy ageing, is defined by WHO as" the composite
of all the physical and mental capacities that an individual can draw on at any point in time" …

Understanding long COVID; mitochondrial health and adaptation—old pathways, new problems

AVW Nunn, GW Guy, W Brysch, JD Bell - Biomedicines, 2022 - mdpi.com
Many people infected with the SARS-CoV-2 suffer long-term symptoms, such as “brain fog”,
fatigue and clotting problems. Explanations for “long COVID” include immune imbalance …

The long-term health outcomes, pathophysiological mechanisms and multidisciplinary management of long COVID

J Li, Y Zhou, J Ma, Q Zhang, J Shao, S Liang… - … and Targeted Therapy, 2023 - nature.com
There have been hundreds of millions of cases of coronavirus disease 2019 (COVID-19),
which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With …

Functional limitations and exercise intolerance in patients with post-COVID condition: a randomized crossover clinical trial

A Tryfonos, K Pourhamidi, G Jörnåker… - JAMA Network …, 2024 - jamanetwork.com
Importance Many patients with post-COVID condition (PCC) experience persistent fatigue,
muscle pain, and cognitive problems that worsen after exertion (referred to as postexertional …

[HTML][HTML] Long COVID: Clinical characteristics, proposed pathogenesis and potential therapeutic targets

G Kenny, L Townsend, S Savinelli… - Frontiers in Molecular …, 2023 - frontiersin.org
The emergence of persistent ill-health in the aftermath of SARS-CoV-2 infection has
presented significant challenges to patients, healthcare workers and researchers. Termed …