Innate immunity: a common denominator between neurodegenerative and neuropsychiatric diseases

F Novellino, V Saccà, A Donato, P Zaffino… - International journal of …, 2020 - mdpi.com
The intricate relationships between innate immunity and brain diseases raise increased
interest across the wide spectrum of neurodegenerative and neuropsychiatric disorders …

C‐reactive protein: Marker of risk for post‐traumatic stress disorder and its potential for a mechanistic role in trauma response and recovery

SF Friend, R Nachnani, SB Powell… - European Journal of …, 2022 - Wiley Online Library
Increasing evidence indicates that inflammation plays a role in PTSD and stress disorder
pathophysiology. PTSD is consistently associated with higher circulating inflammatory …

Neuroprotective versus neuroinflammatory roles of complement: from development to disease

M Kanmogne, RS Klein - Trends in neurosciences, 2021 - cell.com
Complement proteins are ancient components of innate immunity that have emerged as
crucial regulators of neural networks. We discuss these roles in the context of the CNS …

Integrative multiomics and regulatory network analyses uncovers the role of OAS3, TRAFD1, MiR-222-3p, and MiR-125b-5p in hepatitis E virus infection

S Gupta, P Singh, A Tasneem, A Almatroudi… - Genes, 2022 - mdpi.com
The hepatitis E virus (HEV) is a long-ignored virus that has spread globally with time. It
ranked 6 th among the top risk-ranking viruses with high zoonotic spillover potential; thus …

Resilience against traumatic stress: current developments and future directions

C Snijders, LK Pries, N Sgammeglia, G Al Jowf… - Frontiers in …, 2018 - frontiersin.org
Given the high prevalence of stress-related mental disorders, their impact on person, family,
and society and the paucity of treatment options for most of these disorders, there is currently …

Master regulator genes and their impact on major diseases

W Cai, W Zhou, Z Han, J Lei, J Zhuang, P Zhu, X Wu… - PeerJ, 2020 - peerj.com
Master regulator genes (MRGs) have become a hot topic in recent decades. They not only
affect the development of tissue and organ systems but also play a role in other signal …

Central and peripheral immune dysregulation in posttraumatic stress disorder: convergent multi-omics evidence

DL Nunez-Rios, JJ Martinez-Magana, ST Nagamatsu… - Biomedicines, 2022 - mdpi.com
Posttraumatic stress disorder (PTSD) is a chronic and multifactorial disorder with a
prevalence ranging between 6–10% in the general population and~ 35% in individuals with …

The proteome and its dynamics: a missing piece for integrative multi-omics in schizophrenia

KE Borgmann-Winter, K Wang, S Bandyopadhyay… - Schizophrenia …, 2020 - Elsevier
The complex and heterogeneous pathophysiology of schizophrenia can be deconstructed
by integration of large-scale datasets encompassing genes through behavioral phenotypes …

TRPs in ovarian serous cystadenocarcinoma: The expression patterns, prognostic roles, and potential therapeutic targets

C Zhang, C Xu, C Ma, Q Zhang, S Bu… - Frontiers in Molecular …, 2022 - frontiersin.org
Ovarian cancer (usually ovarian serous cystadenocarcinoma, or OV) is the fifth leading
cause of cancer-related deaths in women, with more than 184,000 deaths reported …

Transcriptional network analysis on brains reveals a potential regulatory role of PPP1R3F in autism spectrum disorders

A Doostparast Torshizi, J Duan, K Wang - BMC Research Notes, 2018 - Springer
Objective This study aims at identifying master regulators of transcriptional networks in
autism spectrum disorders (ASDs). Results With two sets of independent RNA-Seq data …