Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Aging accompanied by several age-related complications, is a multifaceted inevitable
biological progression involving various genetic, environmental, and lifestyle factors. The …

Mature adipocytes are generated through the proliferation and differentiation of precursor
cells. Our previous studies identified adipocyte progenitors in white adipose tissue (WAT) as …

Abstract The methyltransferase, Enhancer of Zeste homology 2 (EZH2), trimethylates histone
3 lysine 27 (H3K27me3) on chromatin and this repressive mark is removed by lysine …

Obesity-associated metabolic abnormalities comprise a cluster of conditions including
dyslipidemia, insulin resistance, diabetes and cardiovascular diseases that has affected …

Mesenchymal stem cells (MSCs) are multipotent cells that can differentiate into various cell
types and have been widely used in tissue engineering application. In tissue engineering, a …

Brown adipose tissue (BAT) is specialized to burn lipids for heat generation as a natural
defense against cold and obesity. Previous studies established microRNAs (miRNAs) as …

Experimental evidence indicates that mesenchymal stromal cells (MSCs) may regulate
tumor microenvironment (TME). It is conceivable that the interaction with MSC can influence …

Tissue growth and maintenance requires stem cell populations that self-renew, proliferate,
and differentiate. Maintenance of white adipose tissue (WAT) requires the proliferation and …

Deregulation of protein tyrosine kinase (PTK) activity is implicated in various proliferative
conditions. Multi-target tyrosine kinase inhibitors (TKIs) are increasingly used for the …