Cytokines play a central role in the pathophysiology of autoimmune and inflammatory
diseases. Several cytokines signal through the JAK-STAT pathway, which is now recognized …

Janus kinase (JAK) inhibitors have become promising treatments for atopic dermatitis (AD),
however no study directly comparing JAK inhibitors with each other has been reported. We …

Human skin pigmentation and melanin synthesis are incredibly variable, and are impacted
by genetics, UV exposure, and some drugs. Patients' physical appearance, psychological …

Background Upadacitinib is an oral Janus kinase (JAK) inhibitor with greater inhibitory
potency for JAK1 than JAK2, JAK3, and tyrosine kinase 2. We aimed to assess the efficacy …

Atopic dermatitis is a common, chronic, immune-mediated disease associated with several
comorbidities. Elevated levels of T helper (Th) 2, Th22, and also some Th1 and Th17 …

In this era, it is axiomatic that cytokines have critical roles in cellular development and
differentiation, immune homeostasis, and host defense. Equally, dysregulation of cytokines …

The Janus kinase–signal transducer and activator of transcription pathway is a conserved
master regulator of immunity and myeloproliferation. Advanced understanding of this …

Autoimmune-mediated inflammatory skin diseases, such as psoriasis, alopecia areata, and
vitiligo, have been reported as the 4th leading cause of nonfatal disease burden worldwide …

Dermatomyositis is a rare inflammatory disease with characteristic cutaneous findings and
varying amounts of systemic involvement. Patients may present with skin disease alone …

Abstract Introduction The JAK/STAT signaling pathway is involved in the immune-mediated
inflammatory skin diseases atopic dermatitis (AD), vitiligo, and alopecia areata (AA), and …