RNA modification has recently become a significant process of gene regulation, and the
methyltransferase-like (METTL) family of proteins plays a critical role in RNA modification …

RNA methylation is a critical mechanism for regulating the transcription and translation of
specific sequences or for eliminating unnecessary sequences during RNA maturation …

Cancer is a global public health problem that is related to different environmental and
lifestyle factors. Although the combination of screening, prevention, and treatment of cancer …

Cardiovascular diseases lead the mortality and morbidity disease metrics worldwide. A
multitude of chemical base modifications in ribonucleic acids (RNAs) have been linked with …

A wide variety of chemicals are ubiquitous in the environment and thus exposure to these
environmental chemicals poses a serious threat to public health. Particularly, environmental …

N6-methyladenosine (m6A) is the most pervasive RNA modification in eukaryotic cells. The
dynamic and reversible m6A modification of RNA plays a critical role in the occurrence and …

Chromatin has an extremely flexible structure that allows the fine regulation of gene
expression. To orchestrate this process, small chemical modifications are dynamically …

Abstract In mammals, N 6-methyladenosine (m 6 A) is thought to be the most common and
conserved mRNA modification. Methyltransferase-like 3 (METTL3) is the primary regulator of …

RNA modification is considered as an epigenetic modification that plays an indispensable
role in biological processes such as gene expression and genome editing without altering …

Chemical modifications are a specific and efficient way to regulate the function of biological
macromolecules. Among them, RNA molecules exhibit a variety of modifications that play …