[HTML][HTML] N6-methyladenosine (m6A) modification in hepatocellular carcinoma

H Ma, Y Hong, Z Xu, Z Weng, Y Yang, D Jin… - Biomedicine & …, 2024 - Elsevier
Hepatocellular carcinoma (HCC) is one of the deadliest cancers of human, the tumor-related
death of which ranks third among the common malignances. N 6 methyladenosine (m 6 A) …

Multi-dimensional structural footprint identification for the design of potential scaffolds targeting METTL3 in cancer treatment from natural compounds

AR Issahaku, SM Mncube, C Agoni, SK Kwofie… - Journal of Molecular …, 2023 - Springer
Abstract Context N 6-adenosine-methyltransferase (METTL3) is the catalytic domain of the
'writer'proteins which is involved in the post modifications of N 6-methyladinosine (m 6 A) …

RNA modifications in gynecological cancer: current status and future directions

W He, X Hong, G Chen, X Luo, Y Lin - Frontiers in Medicine, 2024 - frontiersin.org
Currently, more than 170 modifications have been identified on RNA. RNA modification
mainly regulates RNA splicing, intracellular transport, degradation, translation, and stability …

[HTML][HTML] The diverse role of RNA methylation in esophageal cancer: RNA methylation in esophageal cancer

W Meng, Y Han, B Li, H Li - Acta biochimica et biophysica Sinica, 2023 - ncbi.nlm.nih.gov
Esophageal cancer is one of the major life-threatening diseases in the world. RNA
methylation is the most common post-transcriptional modification and a wide-ranging …

[HTML][HTML] Biomarkers in acute myeloid leukemia: From state of the art in risk classification to future challenges of RNA editing as disease predictor and therapy target

A Quattrocchi, LV Cappelli, G De Simone… - Aspects of Molecular …, 2023 - Elsevier
Abstract Acute Myeloid Leukemia (AML) is currently diagnosed based on morphological
assessment of myeloid cells' features, immunophenotypic characterization of specific cell …

N6-methyladenosine methylation in ophthalmic diseases: From mechanisms to potential applications

B Li, Z Wang, H Zhou, J Zou, S Yoshida, Y Zhou - Heliyon, 2023 - cell.com
Abstract N6-methyladenosine (m 6 A) modification, as the most common modification
method in eukaryotes, is widely involved in numerous physiological and pathological …

Emerging role of N6-methyladenosine in the homeostasis of glucose metabolism

YH Sun, TJ Zhao, LH Li, Z Wang… - American Journal of …, 2024 - journals.physiology.org
N 6-methyladenosine (m6A) is the most prevalent post-transcriptional internal RNA
modification, which is involved in the regulation of diverse physiological processes. Dynamic …

Targeting RNA modifications with pharmacological agents: New frontiers in cancer therapy

A Guan, JJL Wong - Cancer Medicine, 2024 - Wiley Online Library
Abstract The N6‐methyladenosine (m6A) RNA modification has gained significant
prominence as a new layer of regulatory mechanism that governs gene expression. Over the …

[HTML][HTML] Insights into the role of RNA m6A modification in the metabolic process and related diseases

H Hu, Z Li, X Xie, Q Liao, Y Hu, C Gong, N Gao… - Genes & …, 2024 - Elsevier
According to the latest consensus, many traditional diseases are considered metabolic
diseases, such as cancer, type 2 diabetes, obesity, and cardiovascular disease. Currently …

Methylation modifications in tRNA and associated disorders: Current research and potential therapeutic targets

Z Wu, R Zhou, B Li, M Cao, W Wang, X Li - Cell Proliferation, 2024 - Wiley Online Library
High‐throughput sequencing has sparked increased research interest in RNA modifications,
particularly tRNA methylation, and its connection to various diseases. However, the precise …