Regulatory role of RNA modifications in the treatment of pancreatic ductal adenocarcinoma (PDAC)
H Chen, W Luo, X Lu, T Zhang - Heliyon, 2023 - cell.com
Pancreatic ductal adenocarcinoma (PDAC) is an extremely life-threatening malignancy with
a relatively unfavorable prognosis. The early occurrence of metastasis and local recurrence …
a relatively unfavorable prognosis. The early occurrence of metastasis and local recurrence …
Recent Advances of RNA m6A Modifications in Cancer Immunoediting and Immunotherapy
Cancer immunotherapy, which modulates immune responses against tumors using immune-
checkpoint inhibitors or adoptive cell transfer, has emerged as a novel and promising …
checkpoint inhibitors or adoptive cell transfer, has emerged as a novel and promising …
Epigenetic therapeutic strategies in pancreatic cancer.
A Orlacchio, S Muzyka, TA Gonda - International Review of Cell and …, 2024 - europepmc.org
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid malignancies,
characterized by its aggressiveness and metastatic potential, with a 5-year survival rate of …
characterized by its aggressiveness and metastatic potential, with a 5-year survival rate of …
Small Molecule Inhibitors Targeting Methyltransferase-Like (METTL) Proteins Against Hepatocellular Carcinoma: A Comprehensive Drug Repurposing Approach
MN Morshed, MSA Parvez, RI Akanda, MK Saha… - bioRxiv, 2023 - biorxiv.org
An efficient and durable multi-targeted therapeutic drug against hepatocellular carcinoma
(HCC) has recently been a growing concern for tackling the chemoresistance of approved …
(HCC) has recently been a growing concern for tackling the chemoresistance of approved …
Epi-Drugs Targeting RNA Dynamics in Cancer
G Bove, I Lettiero, G Sgueglia, N Del Gaudio… - Cancer Research: An …, 2023 - Springer
From the early discovery of ribonucleic acid in 1868, the RNA world has seen constant
evolution. To date, more than ten types of RNA species are recognized and have been …
evolution. To date, more than ten types of RNA species are recognized and have been …
Per-Residue Footprints Guided Pharmacophore Model and Pharmacokinetic Profiles for the Discovery of Potential METTL3 Inhibitors Against Myeloid Leukemia
SM Mncube, AR Issahaku, MES Soliman - 2024 - researchsquare.com
The impact of the protein METTL3 on tumorigenesis is well-established in cancer research. It
promotes cell growth, invasion, migration, and drug resistance. METTL3 is also involved in …
promotes cell growth, invasion, migration, and drug resistance. METTL3 is also involved in …
METTL3 Dependent M6A Regulates Chromatin Modifiers in Epithelial Development
AMM López - 2023 - search.proquest.com
Abstract N6-methyladenosine (m 6 A) is the most abundant modification on mammalian
messenger RNAs (mRNAs). It is catalyzed co-transcriptionally by methyltransferase-like …
messenger RNAs (mRNAs). It is catalyzed co-transcriptionally by methyltransferase-like …