Intercellular signaling molecules, known as morphogens, act at a long range in developing
tissues to provide spatial information and control properties such as cell fate and tissue …

Metazoan embryos develop from a single cell into three-dimensional structured organisms
while groups of genetically identical cells attain specialized identities. Cells of the …

Praise for the first edition:… superb, beautifully written and organized work that takes an
engineering approach to systems biology. Alon provides nicely written appendices to …

Biological regulatory systems, such as cell signaling networks, nervous systems and
ecological webs, consist of complex dynamical interactions among many components …

YAP is a transcriptional regulator that controls pluripotency, cell fate, and proliferation. How
cells ensure the selective activation of YAP effector genes is unknown. This knowledge is …

Computational properties of neuronal networks have been applied to computing systems
using simplified models comprising repeated connected nodes, eg, perceptrons, with …

The spatial organization of microbial communities arises from a complex interplay of biotic
and abiotic interactions, and is a major determinant of ecosystem functions. Here we design …

ABSTRACT A handful of core intercellular signaling pathways play pivotal roles in a broad
variety of developmental processes. It has remained puzzling how so few pathways can …

Cells receive a wide range of dynamic signaling inputs during immune regulation, but how
gene regulatory networks measure such dynamic inputs is not well understood. Here, we …

Several conceptual pillars form the foundation of modern immunology, including the clonal
selection theory, antigen receptor diversity, immune memory, and innate control of adaptive …