Cell types are the basic functional units of an organism. Cell types exhibit diverse
phenotypic properties at multiple levels, making them challenging to define, categorize, and …

How are individual cell behaviors coordinated toward invariant large-scale anatomical
outcomes in development and regeneration despite unpredictable perturbations …

Single-cell RNA sequencing (scRNA-seq) has become an empowering technology to profile
the transcriptomes of individual cells on a large scale. Early analyses of differential …

Single-cell biology is facing a crisis of sorts. Vast numbers of single-cell molecular profiles
are being generated, clustered and annotated. However, this is overwhelmingly ad hoc, and …

Dynamic cell identities underlie flexible developmental programs. The stomatal lineage in
the Arabidopsis leaf epidermis features asynchronous and indeterminate divisions that can …

Background and aims Molecular evidence of cellular heterogeneity in the human exocrine
pancreas has not been yet established, due to the local concentration and cascade of …

Despite their importance in tissue homeostasis and renewal, human pituitary stem cells
(PSCs) are incompletely characterized. We describe a human single nucleus RNA-seq and …

The heterocellular nature of the heart has been receiving increasing attention in recent
years. In addition to cardiomyocytes as the prototypical cell type of the heart, non-myocytes …

Understanding the cellular constituents of the prostate is essential for identifying the cell of
origin for prostate adenocarcinoma. Here, we describe a comprehensive single-cell atlas of …

Complex gene regulatory mechanisms underlie differentiation and reprogramming.
Contemporary single-cell lineage-tracing (scLT) methods use expressed, heritable DNA …