The BRCA1 protein, a hereditary breast and ovarian cancer-causing gene product, is known
as a multifunctional protein that performs various functions in cells. It is well known, along …

Background DNA repair pathways, cell cycle arrest checkpoints, and cell death induction are
present in cells to process DNA damage and prevent genomic instability caused by various …

Introduction The prevalence of ischemic heart disease has reached pandemic levels
worldwide. Early revascularization is currently the most effective therapy for ischemic heart …

Abstract Natriuretic peptide receptor 3 (NPR3), mediates natriuretic peptides degradation,
was reported to act as a tumor suppressor or promoter in some types of cancer. Previous …

Ischemia reperfusion (IR) injury plays a pivotal role in many diseases and leads to collateral
damage during surgical interventions. While most studies focus on alleviating its severity in …

Mutations in breast cancer-associated 1 (BRCA1) increase the lifetime risk of developing
breast cancer by up to 51% over the risk of the general population. Many aspects of this …

Background Hypoxic pulmonary hypertension (HPH) is a syndrome of abnormally elevated
pulmonary artery pressure, and it is mostly caused by vasoconstriction and remodeling of …

Objectives: To investigate any gender effect of the beta-1 adrenergic blocker, landiolol, on
cardiac performance and energy metabolism in septic rats, and to explore the expression of …

Abstract Natriuretic Peptide Receptor 3 (NPR3), the clearance receptor for extracellular bio-
active natriuretic peptides (NPs), plays important roles in the homeostasis of body fluid …

Background: The molecular mechanisms underlying obstructive sleep apnea (OSA) and its
comorbidities may involve mitochondrial dysfunction. However, very little is known about the …