Anthrax toxin consists of three nontoxic proteins that self-assemble at the surface of receptor-
bearing mammalian cells or in solution, yielding a series of toxic complexes. Two of the …

Much attention has been focused on anthrax toxin recently, both because of its central role
in the pathogenesis of Bacillus anthracis and because it has proven to be one of the most …

Synaptic neurotransmitter release is driven by Ca2+ influx through active zone voltage-
gated calcium channels (VGCCs),. Control of active zone VGCC abundance and function …

All auxiliary α2δ subunits of voltage-gated Ca2+ (CaV) channels contain an extracellular
Von Willebrand factor-A (VWA) domain that, in α2δ-1 and-2, has a perfect metal-ion …

Anthrax toxin consists of the proteins protective antigen (PA), lethal factor (LF) and oedema
factor (EF). The first step of toxin entry into host cells is the recognition by PA of a receptor on …

The bipolar mitotic spindle is responsible for segregating sister chromatids at anaphase.
Microtubule motor proteins generate spindle bipolarity and enable the spindle to perform …

After binding to cellular receptors and proteolytic activation, the protective antigen
component of anthrax toxin forms a heptameric prepore. The prepore later undergoes pH …

The past five years have led to a tremendous increase in our molecular understanding of the
mode of action of the anthrax toxin, one of the two main virulence factors produced by …

Background: To avoid pathological platelet aggregation by von Willebrand factor (VWF),
VWF multimers are regulated in size and reactivity for adhesion by ADAMTS13‐mediated …

Successful colonization of the host by bacterial pathogens relies on their capacity to evade
the complex and powerful defenses opposed by the host immune system, at least in the …