Investigating the Influence of ANTXR2 Gene Mutations on Protective Antigen Binding for Heightened Anthrax Resistance

CA Archana, YS Sekar, KP Suresh, S Subramaniam… - Genes, 2024 - mdpi.com
Bacillus anthracis is the bacterium responsible for causing the zoonotic disease called
anthrax. The disease presents itself in different forms like gastrointestinal, inhalation, and …

A receptor-based switch that regulates anthrax toxin pore formation

RM Pilpa, M Bayrhuber, JM Marlett, R Riek… - PLoS …, 2011 - journals.plos.org
Cellular receptors can act as molecular switches, regulating the sensitivity of microbial
proteins to conformational changes that promote cellular entry. The activities of these …

Transgenic expression of the von Willebrand A domain of the BONZAI 1/COPINE 1 protein triggers a lesion-mimic phenotype in Arabidopsis

J Liu, N Jambunathan, TW McNellis - Planta, 2005 - Springer
The copines are a newly identified, widely distributed class of Ca 2+-dependent,
phospholipid-binding proteins that may be involved in cellular signaling. The copines have a …

Systemic hyalinosis mutations in the CMG2 ectodomain leading to loss of function through retention in the endoplasmic reticulum

J Deuquet, L Abrami, A Difeo, MCM Ramirez… - Human …, 2009 - Wiley Online Library
Systemic hyalinosis is an autosomal recessive disease that encompasses two allelic
syndromes, infantile systemic hyalinosis (ISH) and juvenile hyaline fibromatosis (JHF) …

Anti‐infective immunoadhesins from plants

K Wycoff, J Maclean, A Belle, L Yu… - Plant biotechnology …, 2015 - Wiley Online Library
Immunoadhesins are recombinant proteins that combine the ligand‐binding region of a
receptor or adhesion molecule with immunoglobulin constant domains. All FDA‐approved …

A novel COCH mutation associated with autosomal dominant nonsyndromic hearing loss disrupts the structural stability of the vWFA2 domain

HJ Cho, HJ Park, M Trexler, H Venselaar… - Journal of molecular …, 2012 - Springer
Mutations in COCH have been associated with autosomal dominant nonsyndromic hearing
loss (DFNA9) and are frequently accompanied by vestibular hypofunction. Here, we report …

A three-way inter-molecular network accounts for the CaVα2δ1-induced functional modulation of the pore-forming CaV1. 2 subunit

J Briot, O Mailhot, B Bourdin, MP Tétreault… - Journal of Biological …, 2018 - ASBMB
L-type Ca V 1.2 channels are essential for the excitation–contraction coupling in
cardiomyocytes and are hetero-oligomers of a pore-forming Ca V α1C assembled with Ca V …

Domain 4 of the anthrax protective antigen maintains structure and binding to the host receptor CMG2 at low pH

AS Williams, S Lovell, A Anbanandam… - Protein …, 2009 - Wiley Online Library
Domain 4 of the anthrax protective antigen (PA) plays a key role in cellular receptor
recognition as well as in pH-dependent pore formation. We present here the 1.95 Acrystal …

[HTML][HTML] Ca2+-based allosteric switches and shape shifting in RGLG1 VWA domain

Q Wang, YY Chen, SP Li, WD Yang, LF Sun… - Computational and …, 2020 - Elsevier
RGLG1 is an E3 ubiquitin ligase in Arabidopsis thaliana that participates in ABA signaling
and regulates apical dominance. Here, we present crystal structures of RGLG1 VWA …

Ultrasensitive diagnosis for an anthrax-protective antigen based on a polyvalent directed peptide polymer coupled to zinc oxide nanorods.

HY Park, V Gedi, J Kim, HC Park, SH Han… - … (Deerfield Beach, Fla.), 2011 - europepmc.org
A flexible poly-D-lysine polymer conjugated with different target-binding peptides is
demonstrated with an ultralow concentration detection limit compared to those of other …