Drug development digital twins for drug discovery, testing and repurposing: a schema for requirements and development

G An, C Cockrell - Frontiers in systems biology, 2022 - frontiersin.org
There has been a great deal of interest in the concept, development and implementation of
medical digital twins. This interest has led to wide ranging perceptions of what constitutes a …

Artificial Intelligence and Anticancer Drug Development—Keep a Cool Head

C Bailleux, J Gal, E Chamorey, B Mograbi, G Milano - Pharmaceutics, 2024 - mdpi.com
Artificial intelligence (AI) is progressively spreading through the world of health, particularly
in the field of oncology. AI offers new, exciting perspectives in drug development as toxicity …

Modeling the disruption of respiratory disease clinical trials by non-pharmaceutical COVID-19 interventions

S Arsène, C Couty, I Faddeenkov, N Go… - Nature …, 2022 - nature.com
Respiratory disease trials are profoundly affected by non-pharmaceutical interventions
(NPIs) against COVID-19 because they perturb existing regular patterns of all seasonal viral …

General, open-source vertex modeling in biological applications using Tissue Forge

TJ Sego, T Comlekoglu, SM Peirce, DW Desimone… - Scientific Reports, 2023 - nature.com
Vertex models are a widespread approach for describing the biophysics and behaviors of
multicellular systems, especially of epithelial tissues. Vertex models describe a wide variety …

SimService: a lightweight library for building simulation services in Python

TJ Sego - Bioinformatics, 2024 - academic.oup.com
Integrative biological modeling requires software infrastructure to launch, interconnect, and
execute simulation software components without loss of functionality. SimService is a …

Facilitating automated conversion of scientific knowledge into scientific simulation models with the Machine Assisted Generation, Calibration, and Comparison …

C Cockrell, S Christley, G An - arXiv preprint arXiv:2204.10382, 2022 - arxiv.org
The Machine Assisted Generation, Comparison, and Calibration (MAGCC) framework
provides machine assistance and automation of recurrent crucial steps and processes in the …

Critical Appraisal and Future Challenges of Artificial Intelligence and Anticancer Drug Development

E Chamorey, J Gal, B Mograbi, G Milano - Pharmaceuticals, 2024 - mdpi.com
The conventional rules for anti-cancer drug development are no longer sufficient given the
relatively limited number of patients available for therapeutic trials. It is thus a real challenge …

[PDF][PDF] Developing a Framework for Multi-Scale Modeling of the Digital Patient: Insights from Current Status and Future Directions.

CD Combs, L Pinky, C Ranathunge, S Patel, T Cuper… - SIMULTECH, 2023 - scitepress.org
The Digital Patient is an analytic platform that has the potential to transform personal and
public healthcare, pharmaceutical research, medical device development, and patient and …

[PDF][PDF] The effectiveness of psycho-educational family-oriented interventions based on the integration of systemic approaches on the dimensions of family functioning

P Pirsaghi - Journal of Family Relations Studies, 2024 - journal.uma.ac.ir
Objective: The current study investigated the impact of family-oriented psycho-educational
interventions based on integrating systemic approaches on the dimensions of family …