Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions

Y Jamilloux, T Henry, A Belot, S Viel, M Fauter… - Autoimmunity …, 2020 - Elsevier
The coronavirus disease-19 pandemic (COVID-19), which appeared in China in December
2019 and rapidly spread throughout the world, has forced clinicians and scientists to take up …

[HTML][HTML] Emerging treatment strategies for COVID-19 infection

M Gavriatopoulou, I Ntanasis-Stathopoulos… - Clinical and …, 2021 - Springer
The new type of coronavirus (COVID-19), SARS-CoV-2 originated from Wuhan, China and
has led to a worldwide pandemic. COVID-19 is a novel emerging infectious disease caused …

Association between administration of systemic corticosteroids and mortality among critically ill patients with COVID-19: a meta-analysis

JAC Sterne, S Murthy, JV Diaz, AS Slutsky, J Villar… - Jama, 2020 - jamanetwork.com
Importance Effective therapies for patients with coronavirus disease 2019 (COVID-19) are
needed, and clinical trial data have demonstrated that low-dose dexamethasone reduced …

Effect of hydrocortisone on mortality and organ support in patients with severe COVID-19: the REMAP-CAP COVID-19 corticosteroid domain randomized clinical trial

DC Angus, L Derde, F Al-Beidh, D Annane, Y Arabi… - Jama, 2020 - jamanetwork.com
Importance Evidence regarding corticosteroid use for severe coronavirus disease 2019
(COVID-19) is limited. Objective To determine whether hydrocortisone improves outcome for …

On the alert for cytokine storm: immunopathology in COVID‐19

LA Henderson, SW Canna, GS Schulert… - Arthritis & …, 2020 - Wiley Online Library
Poor outcomes in COVID‐19 correlate with clinical and laboratory features of cytokine storm
syndrome. Broad screening for cytokine storm and early, targeted antiinflammatory therapy …

American College of rheumatology clinical guidance for multisystem inflammatory syndrome in children associated with SARS–CoV‐2 and Hyperinflammation in …

LA Henderson, SW Canna, KG Friedman… - Arthritis & …, 2021 - Wiley Online Library
Objective To provide guidance on the management of Multisystem Inflammatory Syndrome
in Children (MIS‐C), a condition characterized by fever, inflammation, and multiorgan …

Intubation and ventilation amid the COVID-19 outbreak: Wuhan's experience

L Meng, H Qiu, L Wan, Y Ai, Z Xue, Q Guo… - …, 2020 - pubs.asahq.org
The COVID-19 outbreak has led to 80,409 diagnosed cases and 3,012 deaths in mainland
China based on the data released on March 4, 2020. Approximately 3.2% of patients with …

American College of Rheumatology clinical guidance for multisystem inflammatory syndrome in children associated With SARS–CoV‐2 and hyperinflammation in …

LA Henderson, SW Canna, KG Friedman… - Arthritis & …, 2020 - Wiley Online Library
Objective To provide guidance on the management of multisystem inflammatory syndrome
in children (MIS‐C), a condition characterized by fever, inflammation, and multiorgan …

Effect of dexamethasone in hospitalized patients with COVID-19–preliminary report

P Horby, WS Lim, J Emberson, M Mafham, J Bell… - MedRxiv, 2020 - medrxiv.org
ABSTRACT Background Coronavirus disease 2019 (COVID-19) is associated with diffuse
lung damage. Corticosteroids may modulate immune-mediated lung injury and reducing …

Epidemiologic features and clinical course of patients infected with SARS-CoV-2 in Singapore

BE Young, SWX Ong, S Kalimuddin, JG Low, SY Tan… - Jama, 2020 - jamanetwork.com
Importance Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in
Wuhan, China, in December 2019 and has spread globally with sustained human-to-human …