The H1N1 influenza A virus, which originated in swine, caused a global pandemic in 2009,
and the highly pathogenic H5N1 avian influenza virus has also caused epidemics in …

SARS-CoV-2 has a positive sense RNA genome of 29.9 kb in size, showing high sequence
similarity to the BAT-CoV, SARS-CoV, MERS-CoV. SARS-CoV-2 is composed of 14 open …

Influenza virus polymerase initiates the biosynthesis of its own mRNAs with capped 10-to 13-
nucleotide fragments cleaved from cellular (pre-) mRNAs. Two activities are required for this …

Seasonal and pandemic influenza have caused high morbidity and mortality worldwide.
Recent emergence of influenza A H5N1 and H1N1 strains has heightened concern …

Influenza is a negative-sense single-stranded RNA virus with segmented genome. Each
segment is encapsidated by a ribonucleoprotein (RNP) complex composed of RNA …

The influenza virus PA endonuclease, which cleaves capped host pre-mRNAs to initiate
synthesis of viral mRNA, is a prime target for antiviral therapy. The diketo acid compound L …

The influenza virus PA endonuclease is an attractive target for the development of novel anti-
influenza virus therapeutics, which are urgently needed because of the emergence of drug …

Influenza virus PA endonuclease has recently emerged as an attractive target for the
development of novel antiviral therapeutics. This is an enzyme with divalent metal ion …

The H1N1 influenza A virus of swine-origin caused pandemics throughout the world in 2009
and the highly pathogenic H5N1 avian influenza virus has also caused epidemics in …

Metal-activated enzymes are important targets in drug discovery in general and for antivirals
in particular. Such proteins contain one or more metal ion cofactors, prevalently located in …