Non-coding RNAs in development and disease: background, mechanisms, and therapeutic approaches
J Beermann, MT Piccoli, J Viereck… - Physiological …, 2016 - journals.physiology.org
Advances in RNA-sequencing techniques have led to the discovery of thousands of non-
coding transcripts with unknown function. There are several types of non-coding linear …
coding transcripts with unknown function. There are several types of non-coding linear …
[HTML][HTML] Role of miRNA and lncRNAs in organ fibrosis and aging
Fibrosis is the endpoint of pathological remodeling. This process contributes to the
pathogenesis of several chronic disorders and aging-associated organ damage. Different …
pathogenesis of several chronic disorders and aging-associated organ damage. Different …
Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease
Idiopathic pulmonary fibrosis (IPF) is a fatal age-associated disease that is characterized by
progressive and irreversible scarring of the lung. The pathogenesis of IPF is not completely …
progressive and irreversible scarring of the lung. The pathogenesis of IPF is not completely …
Glycolytic reprogramming in myofibroblast differentiation and lung fibrosis
Rationale: Dysregulation of cellular metabolism has been shown to participate in several
pathologic processes. However, the role of metabolic reprogramming is not well appreciated …
pathologic processes. However, the role of metabolic reprogramming is not well appreciated …
Epithelial–mesenchymal transition in the pathogenesis of idiopathic pulmonary fibrosis
F Salton, MC Volpe, M Confalonieri - Medicina, 2019 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a serious disease of the lung, which leads to extensive
parenchymal scarring and death from respiratory failure. The most accepted hypothesis for …
parenchymal scarring and death from respiratory failure. The most accepted hypothesis for …
Human bronchial epithelial cell‐derived extracellular vesicle therapy for pulmonary fibrosis via inhibition of TGF‐β‐WNT crosstalk
Idiopathic pulmonary fibrosis (IPF) is characterized by devastating and progressive lung
parenchymal fibrosis, resulting in poor patient prognosis. An aberrant recapitulation of …
parenchymal fibrosis, resulting in poor patient prognosis. An aberrant recapitulation of …
The impact of TGF-β on lung fibrosis: from targeting to biomarkers
IE Fernandez, O Eickelberg - Proceedings of the American Thoracic …, 2012 - atsjournals.org
Transforming growth factor-β (TGF-β) is extensively involved in the development of fibrosis
in different organs. Overproduction or potentiation of its profibrotic effects leads to an …
in different organs. Overproduction or potentiation of its profibrotic effects leads to an …
Revealing the pathogenic and aging-related mechanisms of the enigmatic idiopathic pulmonary fibrosis. an integral model
A growing body of evidence indicates that aberrant activation of alveolar epithelial cells and
fibroblasts in an aging lung plays a critical role in the pathogenesis of idiopathic pulmonary …
fibroblasts in an aging lung plays a critical role in the pathogenesis of idiopathic pulmonary …
Hallmarks of the ageing lung
S Meiners, O Eickelberg… - European Respiratory …, 2015 - Eur Respiratory Soc
Ageing is the main risk factor for major non-communicable chronic lung diseases, including
chronic obstructive pulmonary disease, most forms of lung cancer and idiopathic pulmonary …
chronic obstructive pulmonary disease, most forms of lung cancer and idiopathic pulmonary …
New cellular and molecular mechanisms of lung injury and fibrosis in idiopathic pulmonary fibrosis
IE Fernandez, O Eickelberg - The Lancet, 2012 - thelancet.com
Idiopathic pulmonary fibrosis is a serious and progressive chronic lung disease that is
characterised by altered cellular composition and homoeostasis in the peripheral lung …
characterised by altered cellular composition and homoeostasis in the peripheral lung …