The arginase enzyme developed in early life forms and was maintained during evolution. As
the last step in the urea cycle, arginase cleaves l-arginine to form urea and l-ornithine. The …

Cyclophosphamide (CP) is an important anticancer drug which belongs to the class of
alkylating agent. Cyclophosphamide is mostly used in bone marrow transplantation …

Endothelial cells control vascular tone by releasing nitric oxide (NO) produced by
endothelial NO synthase. The activity of endothelial NO synthase is modulated by the …

The pathological characteristics of atherosclerosis (AS) include lipid accumulation, fibrosis
formation and atherosclerotic plaque produced in artery intima, which leads to vascular …

Steroid-induced osteonecrosis of the femoral head (SONFH) is a disease characterized by
the collapse of the femoral head. SONFH occurs due to the overuse of glucocorticoids (GCs) …

Arterial hypertension is the most important risk factor for the development of cardiovascular
disease. Recently, aircraft noise has been shown to be associated with elevated blood …

We have recently found that diabetes-induced premature senescence of retinal endothelial
cells is accompanied by NOX2-NADPH oxidase-induced increases in the ureohydrolase …

Abdominal aortic aneurysm is a vascular disease which, despite the fact that it shares
common risk factors with atherosclerosis, develops in parallel but as a partly independent …

Increases in reactive oxygen species (ROS) and decreases in nitric oxide (NO) have been
linked to vascular dysfunction during diabetic retinopathy (DR). Diabetes can reduce NO by …

Eicosapentaenoic acid: docosahexaenoic acid (EPA: DHA) 6: 1, an omega-3
polyunsaturated fatty acid formulation, has been shown to induce a sustained formation of …