RAS proteins are essential components of signalling pathways that emanate from cell
surface receptors. Oncogenic activation of these proteins owing to missense mutations is …

Responding to the increased popularity of herbal medicines and other forms of
complementary or alternative medicine world-wide, this reference reviews and evaluates …

Tissue homeostasis is regulated by apoptosis, the cell-suicide programme that is executed
by proteases called caspases. The Bcl2 family of intracellular proteins is the central …

NF‐κB is responsible for upregulating gene products that control cell survival. In this study,
we demonstrate that SIRT1, a nicotinamide adenosine dinucleotide‐dependent histone …

The causes of sporadic human cancer are seldom recognized, but it is estimated that
carcinogen exposure and chronic inflammation are two important underlying conditions for …

During the past 30 years, elucidation of the pathogenesis of rheumatoid arthritis, Crohn's
disease, psoriasis, psoriatic arthritis and ankylosing spondylitis at the cellular and molecular …

Despite its history as a human teratogen, thalidomide is emerging as a treatment for cancer
and inflammatory diseases. Although the evolution of its clinical application could not have …

Cancer cells use aerobic glycolysis preferentially for energy provision, and this metabolic
change is important for tumour growth,. Here, we have found a link between the tumour …

Human acute myelogenous leukemia (AML) is thought to arise from a rare population of
malignant stem cells. Cells of this nature, herein referred to as leukemic stem cells (LSCs) …

Abstract GM-CSF and M-CSF (CSF-1) can enhance macrophage lineage numbers as well
as modulate their differentiation and function. Of recent potential significance for the therapy …