The NK cell–cancer cycle: advances and new challenges in NK cell–based immunotherapies
Natural killer (NK) cells belong to the innate immune system and contribute to protecting the
host through killing of infected, foreign, stressed or transformed cells. Additionally, via …
host through killing of infected, foreign, stressed or transformed cells. Additionally, via …
Emerging role of tumor cell plasticity in modifying therapeutic response
Resistance to cancer therapy is a major barrier to cancer management. Conventional views
have proposed that acquisition of resistance may result from genetic mutations. However …
have proposed that acquisition of resistance may result from genetic mutations. However …
Optimized gene engineering of murine CAR-T cells reveals the beneficial effects of IL-15 coexpression
E Lanitis, G Rota, P Kosti, C Ronet, A Spill… - Journal of Experimental …, 2020 - rupress.org
Limited clinical benefit has been demonstrated for chimeric antigen receptor (CAR) therapy
of solid tumors, but coengineering strategies to generate so-called fourth-generation (4G) …
of solid tumors, but coengineering strategies to generate so-called fourth-generation (4G) …
CD47 as a promising therapeutic target in oncology
H Zhao, S Song, J Ma, Z Yan, H Xie, Y Feng… - Frontiers in …, 2022 - frontiersin.org
CD47 is ubiquitously expressed on the surface of cells and plays a critical role in self-
recognition. By interacting with SIRPα, TSP-1 and integrins, CD47 modulates cellular …
recognition. By interacting with SIRPα, TSP-1 and integrins, CD47 modulates cellular …
Evodiamine suppresses non-small cell lung cancer by elevating CD8+ T cells and downregulating the MUC1-C/PD-L1 axis
ZB Jiang, JM Huang, YJ Xie, YZ Zhang… - Journal of Experimental …, 2020 - Springer
Background Accumulating evidence showed that regulating tumor microenvironment plays a
vital role in improving antitumor efficiency. Programmed Death Ligand 1 (PD-L1) is …
vital role in improving antitumor efficiency. Programmed Death Ligand 1 (PD-L1) is …
Inhibitory receptors and checkpoints in human NK cells, implications for the immunotherapy of cancer
The highly destructive mechanisms by which the immune system faces microbial infections
is under the control of a series of inhibitory receptors. While most of these receptors prevent …
is under the control of a series of inhibitory receptors. While most of these receptors prevent …
[HTML][HTML] Emerging functions of thrombospondin-1 in immunity
S Kaur, DD Roberts - Seminars in Cell & Developmental Biology, 2024 - Elsevier
Thrombospondin-1 is a secreted matricellular glycoprotein that modulates cell behavior by
interacting with components of the extracellular matrix and with several cell surface …
interacting with components of the extracellular matrix and with several cell surface …
Role of CD47 in tumor immunity: a potential target for combination therapy
J Huang, F Liu, C Li, X Liang, C Li, Y Liu, Z Yi… - Scientific Reports, 2022 - nature.com
CD47 performs a vital function in cancer therapy by binding to different SIRPα,
thrombospondin 1, and integrin. However, its role in tumor immunity and its correlation with …
thrombospondin 1, and integrin. However, its role in tumor immunity and its correlation with …
CD47: Beyond an immune checkpoint in cancer treatment
The transmembrane protein, CD47, is recognized as an important innate immune
checkpoint, and CD47-targeted drugs have been in development with the aim of inhibiting …
checkpoint, and CD47-targeted drugs have been in development with the aim of inhibiting …
Loss of CD47 alters CD8+ T cell activation in vitro and immunodynamics in mice
ABSTRACT CD47 has established roles in the immune system for regulating macrophage
phagocytosis and lymphocyte activation, with growing evidence of its cell-intrinsic regulatory …
phagocytosis and lymphocyte activation, with growing evidence of its cell-intrinsic regulatory …