Context The hypothalamic melanocortin 4 receptor (MC4R) pathway serves a critical role in
regulating body weight. Loss of function (LoF) mutations in the MC4R pathway, including …

Obesity rates among children are growing rapidly worldwide, placing massive pressure on
healthcare systems. Untargeted metabolomics can expand our understanding of the …

The concept of metabolic syndrome (MetS) as a cluster of cardiovascular risk factors
(obesity, altered glucose metabolism, dyslipidemia, and hypertension) has been around for …

Abstract Background Bardet–Biedl syndrome is a rare genetic disease associated with
hyperphagia and early-onset, severe obesity. There is limited evidence on how hyperphagia …

Background: Obesity treatment based on glucagon-like peptide-1 receptor agonists (GLP-1
RAs) proved to limit morbidity and mortality in adult population. In children, optimizing …

Background Gene mutations in the leptin-melanocortin signaling cascade lead to
hyperphagia and severe early onset obesity. In most cases, multimodal conservative …

Background Previous studies have analyzed the relationship between screen time and
cardiometabolic disease risk factors among adolescents, but few have examined the …

Pediatric overweight/obesity has assumed epidemic proportions in India. It is associated
with several significant complications and tracks into adulthood. The mainstay of …

Lifestyle modifications focused on diet, physical activity, and behavior have a modest impact
on weight reduction in children, adolescents, and young adults (YA) with overweight and …

Obesity in childhood is a significant global issue, and prevention is key to reducing
prevalence. Healthcare providers can play an important role in the prevention of obesity …