Human organoids in basic research and clinical applications
Organoids are three-dimensional (3D) miniature structures cultured in vitro produced from
either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from …
either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from …
Human disease models in drug development
A Loewa, JJ Feng, S Hedtrich - Nature reviews bioengineering, 2023 - nature.com
Biomedical research is undergoing a paradigm shift towards approaches centred on human
disease models owing to the notoriously high failure rates of the current drug development …
disease models owing to the notoriously high failure rates of the current drug development …
Accelerating antiviral drug discovery: lessons from COVID-19
During the coronavirus disease 2019 (COVID-19) pandemic, a wave of rapid and
collaborative drug discovery efforts took place in academia and industry, culminating in …
collaborative drug discovery efforts took place in academia and industry, culminating in …
A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models
Idiopathic pulmonary fibrosis (IPF) is an aggressive interstitial lung disease with a high
mortality rate. Putative drug targets in IPF have failed to translate into effective therapies at …
mortality rate. Putative drug targets in IPF have failed to translate into effective therapies at …
COVID-19 and kidney disease: insights from epidemiology to inform clinical practice
V Mahalingasivam, G Su, M Iwagami… - Nature Reviews …, 2022 - nature.com
Over the course of the COVID-19 pandemic, numerous studies have aimed to address the
challenges faced by patients with kidney disease and their caregivers. These studies …
challenges faced by patients with kidney disease and their caregivers. These studies …
Human pluripotent-stem-cell-derived organoids for drug discovery and evaluation
Human pluripotent stem cells (hPSCs) and three-dimensional organoids have ushered in a
new era for disease modeling and drug discovery. Over the past decade, significant …
new era for disease modeling and drug discovery. Over the past decade, significant …
[HTML][HTML] A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells
It is not well understood why diabetic individuals are more prone to develop severe COVID-
19. To this, we here established a human kidney organoid model promoting early hallmarks …
19. To this, we here established a human kidney organoid model promoting early hallmarks …
The role of oxidative stress in the pathogenesis of infections with coronaviruses
Coronaviruses can cause serious respiratory tract infections and may also impact other end
organs such as the central nervous system, the lung and the heart. The coronavirus disease …
organs such as the central nervous system, the lung and the heart. The coronavirus disease …
Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury
C Hinze, C Kocks, J Leiz, N Karaiskos, A Boltengagen… - Genome Medicine, 2022 - Springer
Background Acute kidney injury (AKI) occurs frequently in critically ill patients and is
associated with adverse outcomes. Cellular mechanisms underlying AKI and kidney cell …
associated with adverse outcomes. Cellular mechanisms underlying AKI and kidney cell …
MSCs vs. iPSCs: Potential in therapeutic applications
K Thanaskody, AS Jusop, GJ Tye… - Frontiers in Cell and …, 2022 - frontiersin.org
Over the past 2 decades, mesenchymal stem cells (MSCs) have attracted a lot of interest as
a unique therapeutic approach for a variety of diseases. MSCs are capable of self-renewal …
a unique therapeutic approach for a variety of diseases. MSCs are capable of self-renewal …