Mathematical modeling in cancer nanomedicine: a review

P Dogra, JD Butner, Y Chuang, S Caserta, S Goel… - Biomedical …, 2019 - Springer
Cancer continues to be among the leading healthcare problems worldwide, and efforts
continue not just to find better drugs, but also better drug delivery methods. The need for …

In silico modelling of cancer nanomedicine, across scales and transport barriers

NR Stillman, M Kovacevic, I Balaz… - NPJ Computational …, 2020 - nature.com
Nanoparticles promise to improve the treatment of cancer through their increasingly
sophisticated functionalisations and ability to accumulate in certain tumours. Yet recent work …

Meta-analysis of nanoparticle delivery to tumors using a physiologically based pharmacokinetic modeling and simulation approach

YH Cheng, C He, JE Riviere, NA Monteiro-Riviere… - ACS …, 2020 - ACS Publications
Numerous studies have engineered nanoparticles with different physicochemical properties
to enhance the delivery efficiency to solid tumors, yet the mean and median delivery …

Synthetic and living micropropellers for convection-enhanced nanoparticle transport

S Schuerle, AP Soleimany, T Yeh, GM Anand… - Science …, 2019 - science.org
Nanoparticles (NPs) have emerged as an advantageous drug delivery platform for the
treatment of various ailments including cancer and cardiovascular and inflammatory …

Nanoparticle mediated tumor vascular disruption: a novel strategy in radiation therapy

S Kunjachan, A Detappe, R Kumar, T Ireland… - Nano …, 2015 - ACS Publications
More than 50% of all cancer patients receive radiation therapy. The clinical delivery of
curative radiation dose is strictly restricted by the proximal healthy tissues. We propose a …

Antibody-targeted biodegradable nanoparticles for cancer therapy

VH Shargh, H Hondermarck, M Liang - Nanomedicine, 2016 - Taylor & Francis
The use of nanotechnology has great potentials to revolutionize the future cancer diagnosis
and therapy. In this context, various nanoparticles (NPs) have been developed for targeted …

Mechanisms of cooperation in cancer nanomedicine: towards systems nanotechnology

S Hauert, SN Bhatia - Trends in biotechnology, 2014 - cell.com
Nanoparticles are designed to deliver therapeutics and diagnostics selectively to tumors.
Their size, shape, charge, material, coating, and cargo determine their individual …

Fluorescent carbon nanoparticles derived from natural materials of mango fruit for bio-imaging probes

CJ Jeong, AK Roy, SH Kim, JE Lee, JH Jeong, I In… - Nanoscale, 2014 - pubs.rsc.org
Water soluble fluorescent carbon nanoparticles (FCP) obtained from a single natural source,
mango fruit, were developed as unique materials for non-toxic bio-imaging with different …

Advances in targeted nanotherapeutics: from bioconjugation to biomimicry

DM Valcourt, J Harris, RS Riley, M Dang, J Wang… - Nano research, 2018 - Springer
Since the emergence of cancer nanomedicine, researchers have had intense interest in
developing nanoparticles (NPs) that can specifically target diseased sites while avoiding …

[HTML][HTML] Improving nanotherapy delivery and action through image-guided systems pharmacology

TSC Ng, MA Garlin, R Weissleder, MA Miller - Theranostics, 2020 - ncbi.nlm.nih.gov
Despite recent advances in the translation of therapeutic nanoparticles (TNPs) into the clinic,
the field continues to face challenges in predictably and selectively delivering nanomaterials …