Most antimalarials are based on basic N-heterocycles and possess amine functionalities.
Despite this, the role of basic nitrogen (BaN) in antimalarial drug design has not been …

Model‐informed drug development (MIDD) has a long and rich history in infectious
diseases. This review describes foundational principles of translational anti‐infective …

New drugs for visceral leishmaniasis that are safe, low cost, and adapted to the field are
urgently required. Despite concerted efforts over the last several years, the number of new …

The COVID-19 pandemic continues unabated, emphasizing the need for additional antiviral
treatment options to prevent hospitalization and death of patients infected with SARS-CoV-2 …

Dihydroorotate dehydrogenase (DHODH) has been clinically validated as a target for the
development of new antimalarials. Experience with clinical candidate triazolopyrimidine …

Chloroquine (CQ) phosphate has been suggested to be clinically effective in the treatment of
coronavirus disease 2019 (COVID-19). To develop a physiologically-based pharmacokinetic …

Abstract The Paris Agreement aims to constrain global warming to 'well below 2° C'and to
'pursue efforts' to limit it to 1.5° C above pre-industrial levels. We quantify global and …

Solar geoengineering is often framed as a stopgap measure to decrease the magnitude,
impacts, and injustice of climate change. However, the benefits or costs of geoengineering …

Pyronaridine-artesunate was recently strongly recommended in the 2022 update of the
WHO Guidelines for the Treatment of Malaria, becoming the newest artemisinin-based …

A phenotypic high-throughput screen allowed discovery of quinazolinone-2-carboxamide
derivatives as a novel antimalarial scaffold. Structure–activity relationship studies led to …