Introduction Substantial links between autoimmune diseases have been shown by an
increasing number of studies, and one hypothesis for this comorbidity is that there is a …

Background Observational studies have revealed that type 2 diabetes (T2D) is associated
with an increased risk of peripheral artery disease (PAD). However, whether the two …

Aims/hypothesis Type 2 diabetes is a growing global public health challenge. Investigating
quantitative traits, including fasting glucose, fasting insulin and HbA1c, that serve as early …

Introduction Obesity is a complex disease associated with excessive fat accumulation and
numerous metabolic complications. So far, many factors leading to the development of this …

In 2020, the Japan Diabetes Society (JDS) adopted a sweeping decision to release
consensus statements on relevant issues in diabetes management that require updating …

We generated Japanese Encyclopedia of Whole-Genome/Exome Sequencing Library
(JEWEL), a high-depth whole-genome sequencing dataset comprising 3256 individuals …

Genome-wide association studies have revolutionized our understanding of the genetic
underpinnings of cardiometabolic disease. Yet, the inadequate representation of individuals …

Background The epidemiological association between type 2 diabetes and cataract has
been well established. However, it remains unclear whether the two diseases share a …

UK Biobank is a major prospective epidemiological study that is carrying out detailed
multimodal brain imaging on 100,000 participants, and includes genetics and ongoing …

It remains unclear whether the relationship between type 2 diabetes mellitus (T2DM) and
bone mineral density (BMD) reflects causality in East Asian populations. Herein, a …