Wilms tumour (WT) is a childhood embryonal tumour that is paradigmatic of the intersection
between disrupted organogenesis and tumorigenesis. Many WT genes play a critical (non …

Abstract DICER1 syndrome (OMIM 606241, 601200) is a rare autosomal dominant familial
tumor predisposition disorder with a heterozygous DICER1 germline mutation. The most …

Childhood malignancies are rarely related to known environmental exposures, and it has
become increasingly evident that inherited genetic factors play a substantial causal role …

Pediatric renal tumors account for 3%–11% of childhood cancers, the most common of
which is Wilms tumor or nephroblastoma. Epidemiology plays a key role in cancer …

Since previous consensus-based Wilms tumour (WT) surveillance guidelines were
published, novel genes and syndromes associated with WT risk have been identified, and …

Background Wilms' tumor (WT) is the most frequently occurring paediatric renal tumor and is
one of the most treatment-responsive tumors. A tumor-suppressor gene and other genetic …

The algorithm that has been used successfully in the surgical management of unilateral
Wilms tumor, radical nephroureterectomy, cannot be used in children who present with …

SIAH1 has been reported to participate in several human cancers, including hepatocellular
carcinoma (HCC). However, the effect of SIAH1 on the epithelial–mesenchymal transition …

DICER1 syndrome, a rare autosomal dominant genetic disorder, stems from mutations in the
DICER1 gene, disrupting RNA interference and leading to various tumors. These tumors …

Simple Summary The Wilms tumor is the most common kidney cancer in children. This study
characterized complete miRNA and mRNA profiles using a comprehensive NGS …