C Alquezar, S Arya, AW Kao - Frontiers in neurology, 2021 - frontiersin.org
Post-translational modifications (PTMs) on tau have long been recognized as affecting protein function and contributing to neurodegeneration. The explosion of information on …
N ε-lysine acetylation was discovered more than half a century ago as a post-translational modification of histones and has been extensively studied in the context of transcription …
A Tan, R Prasad, C Lee, E Jho - Cell Death & Differentiation, 2022 - nature.com
Transcription factor EB (TFEB), a member of the MiT/TFE family of basic helix-loop-helix leucine zipper transcription factors, is an established central regulator of the …
SE Bates - New England Journal of Medicine, 2020 - Mass Medical Soc
Epigenetic Therapies for Cancer | New England Journal of Medicine Skip to main content The New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …
R Derynck, EH Budi - Science signaling, 2019 - science.org
Encoded in mammalian cells by 33 genes, the transforming growth factor–β (TGF-β) family of secreted, homodimeric and heterodimeric proteins controls the differentiation of most, if …
S Russo, M Kwiatkowski, N Govorukhina… - Frontiers in …, 2021 - frontiersin.org
Diabetes mellitus type II and obesity are two important causes of death in modern society. They are characterized by low-grade chronic inflammation and metabolic dysfunction (meta …
Y Yan, X Wang, D Chaput, MK Shin, Y Koh, L Gan… - Cell, 2022 - cell.com
Although women experience significantly higher tau burden and increased risk for Alzheimer's disease (AD) than men, the underlying mechanism for this vulnerability has not …
INTRODUCTION Cancers persist and progress despite the presence of tumor-infiltrating lymphocytes (TILs). A paradox of tumor immunology is that tumor antigen–specific TILs are …
The cause of insulin resistance in obesity and type 2 diabetes mellitus (T2DM) is not limited to impaired insulin signalling but also involves the complex interplay of multiple metabolic …