Challenges in the diagnosis of Parkinson's disease

E Tolosa, A Garrido, SW Scholz, W Poewe - The Lancet Neurology, 2021 - thelancet.com
Parkinson's disease is the second most common neurodegenerative disease and its
prevalence has been projected to double over the next 30 years. An accurate diagnosis of …

Impact of obstructive sleep apnea on cognitive and motor functions in Parkinson's disease

M Elfil, EI Bahbah, MM Attia, M Eldokmak… - Movement …, 2021 - Wiley Online Library
Introduction Parkinson's disease (PD) is a chronic neurodegenerative disorder that presents
with motor and non‐motor manifestations. Amongst the non‐motor features, various forms of …

Smartwatch inertial sensors continuously monitor real-world motor fluctuations in Parkinson's disease

R Powers, M Etezadi-Amoli, EM Arnold… - Science translational …, 2021 - science.org
Longitudinal, remote monitoring of motor symptoms in Parkinson's disease (PD) could
enable more precise treatment decisions. We developed the Motor fluctuations Monitor for …

Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity

N Ramalingam, SX Jin, TE Moors… - npj Parkinson's …, 2023 - nature.com
In Parkinson's disease and other synucleinopathies, the elevation of α-synuclein
phosphorylated at Serine129 (pS129) is a widely cited marker of pathology. However, the …

Long-term effect of apomorphine infusion in advanced Parkinson's disease: a real-life study

B Meira, B Degos, E Corsetti, M Doulazmi… - npj Parkinson's …, 2021 - nature.com
Long-term effects of continuous subcutaneous apomorphine infusion (CSAI) on health-
related quality of life (HRQoL) and predictors of CSAI discontinuation are poorly known …

Structural plasticity of the hippocampus in neurodegenerative diseases

PDE Weerasinghe-Mudiyanselage, MJ Ang… - International journal of …, 2022 - mdpi.com
Neuroplasticity is the capacity of neural networks in the brain to alter through development
and rearrangement. It can be classified as structural and functional plasticity. The …

Treatment for cognitive and neuropsychiatric non-motor symptoms in Parkinson's disease: current evidence and future perspectives

E Mantovani, C Zucchella, AA Argyriou… - Expert Review of …, 2023 - Taylor & Francis
Introduction Non-motor symptoms (NMS) affect patients with Parkinson's disease (PD) from
the prodromal to the advanced stages. NMS phenotypes greatly vary and have a huge …

CD4+ T‐cell transcription factors in idiopathic REM sleep behavior disorder and Parkinson's disease

E De Francesco, M Terzaghi, E Storelli… - Movement …, 2021 - Wiley Online Library
Background CD4+ T‐cell dysregulation occurs in Parkinson's disease (PD); however, it is
unknown whether it contributes to PD development. The objective of this study was to …

Sexual dysfunctions in Parkinson's disease and their influence on partnership—data of the PRISM study

T Kinateder, D Marinho, D Gruber, L Hatzler… - Brain sciences, 2022 - mdpi.com
Background: Sexual dysfunctions (SD) are common but underreported in Parkinson's
disease (PD) and have negative impacts on the quality of life (QoL) and partnership …

Systematic review of genetic variants associated with cognitive impairment and depressive symptoms in Parkinson's disease

T D'Souza, AP Rajkumar - Acta neuropsychiatrica, 2020 - cambridge.org
Objective: Cognitive impairment and depression are among the most prevalent and most
disabling non-motor symptoms in Parkinson's disease (PD). The genetic factors that are …