Spheroids and organoids are important novel players in medical and life science research.
They are gradually replacing two-dimensional (2D) cell cultures. Indeed, three-dimensional …

High inter-patient variability and high spatial heterogeneity are features of colorectal cancer
(CRC). This may influence the molecular characterization of tumor tissue, now mandatory for …

Metastasis is a major cause of colorectal cancer (CRC) mortality, but its molecular
mechanisms are still not fully understood. Here, we show that upregulated DDX39B …

Carcinomas are complex heterocellular systems containing epithelial cancer cells, stromal
fibroblasts, and multiple immune cell‐types. Cell‐cell communication between these tumor …

Exosomes derived from mesenchymal stem cells (MSCs) are mostly responsible for the
therapeutic effects of MSCs. To show the therapeutic effects of the human bone marrow …

The epithelial–mesenchymal transition (EMT) is a cellular reprogramming process that
occurs during embryonic development and adult tissue homeostasis. This process involves …

Colorectal cancer (CRC) is one of the most common cancer worldwide, with a growing
impact on public health and clinical management. Immunotherapy has shown promise in the …

Long non-coding RNAs (lncRNAs) are longer than 200 nts non-coding transcripts and have
recently emerged as one of the largest and significantly diverse RNA families whereas …

Translating preclinical studies to effective treatment protocols and identifying specific
therapeutic responses in individuals with cancer is challenging. This may arise due to the …

The consensus molecular subtypes (CMS) of colorectal cancer (CRC) is the most widely-
used gene expression-based classification and has contributed to a better understanding of …