Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …

Diabetic sensorimotor peripheral neuropathy (DSPN) is a serious complication of diabetes
mellitus and is associated with increased mortality, lower-limb amputations and distressing …

Aims/hypothesis The term prediabetes is used for individuals who have impaired glucose
metabolism whose glucose or HbA 1c levels are not yet high enough to be diagnosed as …

Vascular complications of diabetes pose a severe threat to human health. Prevention and
treatment protocols based on a single vascular complication are no longer suitable for the …

Background Cluster analyses have proposed different diabetes phenotypes using age, BMI,
glycaemia, homoeostasis model estimates, and islet autoantibodies. We tested whether …

This review takes an inclusive approach to microvascular dysfunction in diabetes mellitus
and cardiometabolic disease. In virtually every organ, dynamic interactions between the …

Peripheral neuropathy is one of the most common complications of both type 1 and type 2
diabetes. Up to half of patients with diabetes develop neuropathy during the course of their …

The pathogenic mechanisms underlying distal symmetric polyneuropathy (DSPN), a
common neuropathy in patients with diabetes mellitus (DM), are not fully understood. Here …

Type 2 diabetes mellitus (T2DM) is characterized by tissue-specific insulin resistance and
pancreatic β-cell dysfunction, which result from the interplay of local abnormalities within …

Diabetic peripheral neuropathy (DPN) is a common chronic complication of diabetes
mellitus. It leads to distressing and expensive clinical sequelae such as foot ulceration, leg …