The anucleate human platelets contain a broad pattern of mRNAs and other RNA
transcripts. The high quantitative similarity of mRNAs in megakaryocytes and platelets from …

Platelets are cellular elements that are physiologically involved in hemostasis, inflammation,
thrombotic events, and various human diseases. There is a link between the activation of …

Background Recent clinical studies have shown that transfusions of adult platelets increase
morbidity and mortality in preterm infants. Neonatal platelets are hyporesponsive to agonist …

Proteomics tools provide a powerful means to identify, detect, and quantify protein-related
details in studies of platelet phenotype and function. Here, we consider how historical and …

Nano-delivery systems have demonstrated great promise in the therapy of cancer. However,
the therapeutic efficacy of conventional nanomedicines is hindered by the clearance of the …

New insights have been gained on the role of platelets beyond thrombosis. Platelets can
accumulate in damaged and inflamed tissues, acting as a sentinel to detect and repair tissue …

Functional genomics and network biology have emerged as interdisciplinary fields that
provide a comprehensive understanding of biological systems. This discussion explored …

Methods We isolated resting umbilical cord blood-derived platelets from healthy full term
neonates (n= 9) and resting blood platelets from healthy adults (n= 7), and compared protein …

Abstract Patients with chronic Myeloproliferative Neoplasms (MPN) including polycythemia
vera (PV) and essential thrombocythemia (ET) exhibit unique clinical features, such as a …

Cardiovascular diseases (CVDs) remain one of the leading causes of morbidity and
mortality worldwide, with genetics being a major risk factor. Genetic cardiovascular disease …