In a recent issue of Cell, Martin-Rufino et al. develop a strategy for performing high-
throughput base-editing CRISPR screens coupled with single-cell readouts in the context of …

In the absence of a suspect the forensic aim is investigative, and the focus is one of
discerning what genotypes best explain the evidence. In traditional systems, the list of …

Precise genome-editing platforms are versatile tools for generating specific, site-directed
DNA insertions, deletions, and substitutions. The continuous enhancement of these tools …

Regulatory genetic variation shapes gene expression, providing an important mechanism
connecting DNA variation and complex traits. The causal relationships between gene …

In a recent study, Martin-Rufino and colleagues combined massively parallel base editing in
primary human hematopoietic stem and progenitor cells (HSPCs) with functional and single …

In recent years, gene editing technology, represented by clustered regularly interspaced
short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) has made a …

Genetic studies have identified thousands of individual disease-associated non-coding
alleles, but identification of the causal alleles and their functions remain critical bottlenecks …

Self-renewal and differentiation are inherent properties of hematopoietic stem cells (HSCs)
that are necessary to support hematopoiesis; however, the underlying mechanisms …

Single nucleotide variants (SNVs) contribute to cancer by altering the coding and the non-
coding regions of the genome. Connecting SNVs to transcriptomic and epigenetic changes …

Our genomes influence nearly every aspect of human biology from molecular and cellular
functions to phenotypes in health and disease. Human genetics studies have now …