[HTML][HTML] An evolutionary perspective of lifespan and epigenetic inheritance

MT Mc Auley - Experimental Gerontology, 2023 - Elsevier
In the last decade epigenetics has come to the fore as a discipline which is central to
biogerontology. Age associated epigenetic changes are routinely linked with pathologies …

A natural bacterial pathogen of C. elegans uses a small RNA to induce transgenerational inheritance of learned avoidance

T Sengupta, J St. Ange, R Kaletsky, RS Moore… - PLoS …, 2024 - journals.plos.org
C. elegans can learn to avoid pathogenic bacteria through several mechanisms, including
bacterial small RNA-induced learned avoidance behavior, which can be inherited …

Paternal dietary macronutrient balance and energy intake drive metabolic and behavioral differences among offspring

AJ Crean, AMN Senior, T Freire, TD Clark… - Nature …, 2024 - nature.com
Paternal diet can influence the phenotype of the next generation, yet, the dietary
components inducing specific responses in the offspring are not identified. Here, we use the …

Identification of intergenerational epigenetic inheritance by whole genome DNA methylation analysis in trios

A Díez-Villanueva, B Martín, F Moratalla-Navarro… - Scientific Reports, 2023 - nature.com
Genome-wide association studies have identified thousands of loci associated with common
diseases and traits. However, a large fraction of heritability remains unexplained. Epigenetic …

Historic obstacles and emerging opportunities in the field of developmental metabolism–lessons from Heidelberg

AM Garfinkel, E Ilker, H Miyazawa… - …, 2024 - journals.biologists.com
The field of developmental metabolism is experiencing a technological revolution that is
opening entirely new fields of inquiry. Advances in metabolomics, small-molecule sensors …

Calling the question: what is mammalian transgenerational epigenetic inheritance?

H Khatib, J Townsend, MA Konkel, G Conidi… - Epigenetics, 2024 - Taylor & Francis
While transgenerational epigenetic inheritance has been extensively documented in plants,
nematodes, and fruit flies, its existence in mammals remains controversial. Several factors …

Paternal starvation affects metabolic gene expression during zebrafish offspring development and lifelong fitness

A Jimenez‐Gonzalez, F Ansaloni… - Molecular …, 2024 - Wiley Online Library
Dietary restriction in the form of fasting is a putative key to a healthier and longer life, but
these benefits may come at a trade‐off with reproductive fitness and may affect the following …

Association between Maternal Birth Weight and Prevalence of Congenital Malformations in Offspring: The Japanese Environment and Children's Study

H Hamada, N Iwama, H Tomita, K Tagami, N Kumagai… - Nutrients, 2024 - mdpi.com
Congenital malformations are functional and structural alterations in embryonic or foetal
development resulting from a variety of factors including maternal health status. This study …

HDAC3 inhibition protects against peripheral and central alterations in an animal model of obesity

FR Machado, SP Boeira, VC Bortolotto… - Pharmacological …, 2023 - Springer
Background Obesity is a multifactorial disease with epigenetic manifestations that increases
the prevalence of associated comorbidities such as metabolic syndrome, cardiovascular …

Identification of intergenerational epigenetic inheritance by whole genome DNA methylation analysis in trios

I Galvan Femenia, A Díez Villanueva… - … Reports, 2023, vol. 13 …, 2023 - diposit.ub.edu
Genome-wide association studies have identified thousands of loci associated with common
diseases and traits. However, a large fraction of heritability remains unexplained. Epigenetic …