Acute respiratory distress syndrome (ARDS) is a life-threatening lung condition that arises
from multiple causes, including sepsis, pneumonia, trauma, and severe coronavirus disease …

There are 78 loci associated with Parkinson's disease in the most recent genome-wide
association study (GWAS), yet the specific genes driving these associations are mostly …

Coronary artery disease (CAD) is a pandemic disease where up to half of the risk is
explained by genetic factors. Advanced insights into the genetic basis of CAD require …

The polygenic architecture of schizophrenia implicates several molecular pathways involved
in synaptic function. However, it is unclear how polygenic risk funnels through these …

Genetic studies of schizophrenia (SCZ) reveal a complex polygenic risk architecture
comprised of hundreds of risk variants, the majority of which are common in the population …

Many of the Alzheimer's disease (AD) risk genes are specifically expressed in microglia and
astrocytes, but how and when the genetic risk localizing to these cell types contributes to AD …

A primary goal of psychiatry is to better understand the pathways that link genetic risk to
psychiatric symptoms. Here, we tested association of diagnosis and endophenotypes with …

Dysfunction of glutamate neurotransmission has been implicated in the pathophysiology of
schizophrenia and may be particularly relevant in severe, treatment-resistant symptoms. The …

We construct non-linear machine learning (ML) prediction models for systolic and diastolic
blood pressure (SBP, DBP) using demographic and clinical variables and polygenic risk …

Once upon a time, many pain researchers turned to genetics in the hope of finding definitive
explanations for painful conditions in which clinical symptoms did not align with the degree …