[HTML][HTML] Characteristics of SARS-CoV-2 and COVID-19

B Hu, H Guo, P Zhou, ZL Shi - Nature reviews microbiology, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible
and pathogenic coronavirus that emerged in late 2019 and has caused a pandemic of acute …

[HTML][HTML] Animal models for COVID-19

C Muñoz-Fontela, WE Dowling, SGP Funnell, PS Gsell… - Nature, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of
coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the …

[HTML][HTML] A Review of the Progress and Challenges of Developing a Vaccine for COVID-19

O Sharma, AA Sultan, H Ding, CR Triggle - Frontiers in immunology, 2020 - frontiersin.org
A novel coronavirus, which has been designated as severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), was first detected in December 2019 in Wuhan China and …

Lessons learned 1 year after SARS-CoV-2 emergence leading to COVID-19 pandemic

KKW To, S Sridhar, KHY Chiu, DLL Hung… - Emerging microbes & …, 2021 - Taylor & Francis
Without modern medical management and vaccines, the severity of the Coronavirus
Disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome (SARS) …

[HTML][HTML] Insights to SARS-CoV-2 life cycle, pathophysiology, and rationalized treatments that target COVID-19 clinical complications

IP Trougakos, K Stamatelopoulos, E Terpos… - Journal of Biomedical …, 2021 - Springer
Background Gaining further insights into SARS-CoV-2 routes of infection and the underlying
pathobiology of COVID-19 will support the design of rational treatments targeting the life …

Syncytia formation by SARS‐CoV‐2‐infected cells

J Buchrieser, J Dufloo, M Hubert, B Monel… - The EMBO …, 2020 - embopress.org
Severe cases of COVID‐19 are associated with extensive lung damage and the presence of
infected multinucleated syncytial pneumocytes. The viral and cellular mechanisms …

[HTML][HTML] Integrative imaging reveals SARS-CoV-2-induced reshaping of subcellular morphologies

M Cortese, JY Lee, B Cerikan, CJ Neufeldt… - Cell host & …, 2020 - cell.com
Pathogenesis induced by SARS-CoV-2 is thought to result from both an inflammation-
dominated cytokine response and virus-induced cell perturbation causing cell death. Here …

T‐cell responses and therapies against SARS‐CoV‐2 infection

SM Toor, R Saleh, V Sasidharan Nair, RZ Taha… - …, 2021 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) is caused by SARS‐CoV‐2, a novel
coronavirus strain. Some studies suggest that COVID‐19 could be an immune‐related …

[HTML][HTML] Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease

JW Golden, CR Cline, X Zeng, AR Garrison, BD Carey… - JCI insight, 2020 - ncbi.nlm.nih.gov
The emergence of SARS-CoV-2 has created an international health crisis, and small animal
models mirroring SARS-CoV-2 human disease are essential for medical countermeasure …

Endothelial dysfunction in Covid-19 infection

HM Otifi, BK Adiga - The American journal of the medical sciences, 2022 - Elsevier
COVID-19 is an evolving systemic inflammatory pandemic disease, predominantly affecting
the respiratory system. Associated cardiovascular comorbid conditions result in severe to …