Apelin-13 has protective effects on many neurological diseases, including cerebral
ischemia. Here, we aimed to test Apelin-13's effects on ischemic neurovascular unit (NVU) …

Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) has caused a global
health crisis with significant clinical morbidity and mortality. While angiotensin‐converting …

Although increased mammographic density (MD) has been well established as a marker for
increased breast cancer (BC) risk, its pathobiology is far from understood. Altered …

In Alzheimer's disease (AD), amyloid-β (Aβ) deposits in the cerebrovasculature can result in
neurovascular dysfunction and/or cerebral amyloid angiopathy. The accumulation of Aβ in …

Perlecan is a heparan sulfate proteoglycan protein in the extracellular matrix that structurally
and biochemically supports the cerebrovasculature by dynamically responding to changes …

The mammalian HSPG2 gene encodes the proteoglycan protein core perlecan, which has
important functions in biology including cell adhesion via integrins, binding to the …

Background: Vascular endothelial growth factor (VEGF) stimulates vascular genesis and
angiogenesis. Cerebral Hypoxia-Ischemia (HI) leads to the reduction of vasculature in the …

Alzheimer's disease (AD) is characterized by neuronal death, neurofibrillary tangles, and
senile plaques. Amyloid-beta (Aβ) is the major component of plaques and consists of two …

The sad reality is that in the year 2012, people are still dying or suffering from the extreme
morbidity of ischemic stroke. This tragedy is only compounded by the graveyard full of once …

Integrins such as αvβ3, α5β1 play a key role in angiogenesis regulation, invasion and
metastasis, inflammation, wound healing, etc. The up-regulation of integrin αvβ3 after …