Background The islet basement membrane (BM) is dissociated during the digestion phase
of human islet isolation. A number of studies have demonstrated the beneficial effects …

US20180256686A1 - Compositions and Methods for Treating Ischemia - Google Patents
US20180256686A1 - Compositions and Methods for Treating Ischemia - Google Patents …

Ischemic stroke remains one of the leading causes of long-term disability and death
worldwide, despite being a preventable neurological injury. Efforts in prevention have …

Platelets for transfusion are routinely stored in polyvinyl chloride (PVC) bags at room
temperature under constant agitation. This limits their shelf life to 5 days due to deterioration …

Stem cells, including embryonic stem cells (ESC) and induced pluripotent stem (iPS) cells,
have been speculated as tools for studying development as well as prospective sources for …

Cleaved fragments of the extracellular matrix protein perlecan have been shown to promote
neuroprotection and repair after ischemic stroke. The cysteine proteases cathepsin B and L …

The presently-disclosed subject matter provides methods for preventing ischemia in a cell,
treating ischemia in a subject, and preventing an infarction in a subject that utilize α5β1 …

Perlecan is the large heparan sulfate proteoglycan common to all basement membranes. It
has numerous functions in maintenance of BM integrity, cell signaling and scaffolding …