Adjuvants are vaccine components that enhance the magnitude, breadth and durability of
the immune response. Following its introduction in the 1920s, alum remained the only …

Vaccines are the key technology to combat existing and emerging infectious diseases.
However, increasing the potency, quality and durability of the vaccine response remains a …

Our body has a remarkable ability to remember its past encounters with allergens,
pathogens, wounds and irritants, and to react more quickly to the next experience. This …

Despite the success of the BNT162b2 mRNA vaccine, the immunological mechanisms that
underlie its efficacy are poorly understood. Here we analyzed the innate and adaptive …

Disease and accompanying inflammation are uncommon outcomes of viral infection in
humans. Clinical inflammation occurs if steady-state cell-intrinsic and leukocytic immunity to …

The immense interindividual clinical variability during any infection is a long-standing
enigma. Inborn errors of IFN-γ and IFN-α/β immunity underlying rare infections with weakly …

Senescent cell accumulation has been implicated in the pathogenesis of aging-associated
diseases, including cancer. The mechanism that prevents the accumulation of senescent …

While inbred mice have informed most of what we know about the immune system in the
modern era, they have clear limitations with respect to their ability to be informative …

Tracking and imaging immune cells in vivo non-invasively would offer insights into the
immune responses induced by vaccination. Here we report a cancer vaccine consisting of …

Recent advances in skin-interfaced wearable sweat sensors enable the noninvasive, real-
time monitoring of biochemical signals associated with health and wellness. These …