Materialomics integrates experiment, theory, and computation in a high‐throughput manner,
and has changed the paradigm for the research and development of new functional …

Drug carriers have been commonly used for drug control release, enhancing drug efficacy
and/or minimizing side-effects. However, it is still difficult to get a high loading efficiency …

Lipid nanoparticle (LNP)-mediated nucleic acid therapies, including mRNA protein
replacement and gene editing therapies, hold great potential in treating neurological …

The ischemic stroke is a major global health concern, with high mortality and disability rates.
Unfortunately, there is a dearth of effective clinical interventions for managing poststroke …

Reactive oxygen species (ROS)-mediated oxidative stress exacerbates chronic diseases
such as organ damage and neurodegenerative disorders. The Keap1-Nrf2-ARE pathway is …

The association between dysfunctional microglia and amyloid-β (Aβ) is a fundamental
pathological event and increases the speed of Alzheimer's disease (AD). Additionally, the …

Recently, nucleic acid delivery has become an amazing route for the treatment of various
malignant diseases, and polycationic vectors are attracting more and more attention among …

Cellular uptake of exogenous nucleic acids is inhibited in pathological tissues accompanied
by excessive expression of matrix metalloproteinases (MMPs). We show that CO, as a …

Gene therapy is emerging as a powerful tool to modulate abnormal gene expression, a
hallmark of most CNS disorders. The transformative potentials of recently approved gene …

The lack of safe and efficient therapeutic agent delivery platforms restricts combined
therapy's effect, and combined cancer therapy's multi-component delivery effect needs …