Maternal immune activation and neuroinflammation in human neurodevelopmental disorders

VX Han, S Patel, HF Jones, RC Dale - Nature Reviews Neurology, 2021 - nature.com
Maternal health during pregnancy plays a major role in shaping health and disease risks in
the offspring. The maternal immune activation hypothesis proposes that inflammatory …

Short-and potential long-term adverse health outcomes of COVID-19: a rapid review

TYM Leung, AYL Chan, EW Chan… - Emerging microbes & …, 2020 - Taylor & Francis
ABSTRACT The coronavirus disease 2019 (COVID-19) pandemic has resulted in millions of
patients infected worldwide and indirectly affecting even more individuals through disruption …

Interactions between gender and sepsis—implications for the future

I Lakbar, S Einav, N Lalevée, I Martin-Loeches… - Microorganisms, 2023 - mdpi.com
Sex and gender dimorphisms are found in a large variety of diseases, including sepsis and
septic shock which are more prevalent in men than in women. Animal models show that the …

Maternal immune activation as an epidemiological risk factor for neurodevelopmental disorders: Considerations of timing, severity, individual differences, and sex in …

MB Hall, DE Willis, EL Rodriguez… - Frontiers in …, 2023 - frontiersin.org
Epidemiological evidence suggests that one's risk of being diagnosed with a
neurodevelopmental disorder (NDD)—such as autism, ADHD, or schizophrenia—increases …

Extracellular free water elevations are associated with brain volume and maternal cytokine response in a longitudinal nonhuman primate maternal immune activation …

TA Lesh, AM Iosif, C Tanase, RM Vlasova… - Molecular …, 2023 - nature.com
Maternal infection has emerged as an important environmental risk factor for
neurodevelopmental disorders, including schizophrenia and autism spectrum disorders …

A comprehensive approach to modeling maternal immune activation in rodents

MC Bucknor, A Gururajan, RC Dale… - Frontiers in …, 2022 - frontiersin.org
Prenatal brain development is a highly orchestrated process, making it a very vulnerable
window to perturbations. Maternal stress and subsequent inflammation during pregnancy …

What does immunology have to do with normal brain development and the pathophysiology underlying Tourette syndrome and related neuropsychiatric disorders?

D Martino, I Johnson, JF Leckman - Frontiers in Neurology, 2020 - frontiersin.org
Objective: The goal of this article is to review the past decade's literature and provide a
critical commentary on the involvement of immunological mechanisms in normal brain …

Immune regulation of neurodevelopment at the mother–foetus interface: the case of autism

S Sotgiu, S Manca, A Gagliano… - Clinical & …, 2020 - Wiley Online Library
Autism spectrum disorder (ASD) is a neurodevelopmental disorder defined by deficits in
social communication and stereotypical behaviours. ASD's aetiology remains mostly …

Mitochondria may mediate prenatal environmental influences in autism spectrum disorder

RE Frye, J Cakir, S Rose, RF Palmer, C Austin… - Journal of Personalized …, 2021 - mdpi.com
We propose that the mitochondrion, an essential cellular organelle, mediates the long-term
prenatal environmental effects of disease in autism spectrum disorder (ASD). Many prenatal …

Poly (I: C)-induced maternal immune activation modifies ventral hippocampal regulation of stress reactivity: prevention by environmental enrichment

X Zhao, R Mohammed, H Tran, M Erickson… - Brain, behavior, and …, 2021 - Elsevier
Environmental enrichment (EE) has been successfully implemented in human rehabilitation
settings. However, the mechanisms underlying its success are not understood. Incorporating …