mRNA vaccines in disease prevention and treatment

G Zhang, T Tang, Y Chen, X Huang… - Signal transduction and …, 2023 - nature.com
Abstract mRNA vaccines have emerged as highly effective strategies in the prophylaxis and
treatment of diseases, thanks largely although not totally to their extraordinary performance …

Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches

N Hasan, A Nadaf, M Imran, U Jiba, A Sheikh… - Molecular cancer, 2023 - Springer
Skin cancer is a global threat to the healthcare system and is estimated to incline
tremendously in the next 20 years, if not diagnosed at an early stage. Even though it is …

mRNA Cancer vaccines: construction and boosting strategies

X Liu, P Huang, R Yang, H Deng - ACS nano, 2023 - ACS Publications
In late 2020, the US Food and Drug Administration (FDA) approved a lipid-based mRNA
vaccine for the prevention of COVID-19, which has pushed this field to be more closely …

IL-7: A promising adjuvant ensuring effective T cell responses and memory in combination with cancer vaccines?

Y Zhao, K Wei, H Chi, Z Xia, X Li - Frontiers in Immunology, 2022 - frontiersin.org
Cancer vaccines exhibit specificity, effectiveness, and safety as an alternative
immunotherapeutic strategy to struggle against malignant diseases, especially with the rapid …

Clinical advances and ongoing trials of mRNA vaccines for cancer treatment

CL Lorentzen, JB Haanen, Ö Met, IM Svane - The Lancet Oncology, 2022 - thelancet.com
Years of research exploring mRNA vaccines for cancer treatment in preclinical and clinical
trials have set the stage for the rapid development of mRNA vaccines during the COVID-19 …

Cell-penetrating peptides: Emerging tools for mRNA delivery

H Yokoo, M Oba, S Uchida - Pharmaceutics, 2021 - mdpi.com
Messenger RNAs (mRNAs) were previously shown to have great potential for preventive
vaccination against infectious diseases and therapeutic applications in the treatment of …

[HTML][HTML] mRNA: A promising platform for cancer immunotherapy

B Kong, Y Kim, EH Kim, JS Suk, Y Yang - Advanced Drug Delivery Reviews, 2023 - Elsevier
Messenger RNA (mRNA) is now in the limelight as a powerful tool for treating various
human diseases, especially malignant tumors, thanks to the remarkable clinical outcomes of …

mRNA vaccine with unmodified uridine induces robust type I interferon-dependent anti-tumor immunity in a melanoma model

C Sittplangkoon, MG Alameh, D Weissman… - Frontiers in …, 2022 - frontiersin.org
An mRNA with unmodified nucleosides induces type I interferons (IFN-I) through the
stimulation of innate immune sensors. Whether IFN-I induced by mRNA vaccine is crucial for …

[HTML][HTML] The paradigm shift in treatment from Covid-19 to oncology with mRNA vaccines

J Wei, AM Hui - Cancer Treatment Reviews, 2022 - Elsevier
Abstract mRNA vaccines have gained popularity over the last decade as a versatile tool for
developing novel therapeutics. The recent success of coronavirus disease (COVID-19) …

Advances in Nonviral mRNA Delivery Materials and Their Application as Vaccines for Melanoma Therapy

B Neill, AR Romero, OS Fenton - ACS Applied Bio Materials, 2023 - ACS Publications
Messenger RNA (mRNA) vaccines are promising platforms for cancer immunotherapy
because of their potential to encode for a variety of tumor antigens, high tolerability, and …