[HTML][HTML] Cytokines and chemokines in SARS-CoV-2 infections—therapeutic strategies targeting cytokine storm
A Pum, M Ennemoser, T Adage, AJ Kungl - Biomolecules, 2021 - mdpi.com
The recently identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
virus, the cause of coronavirus disease (COVID-19) and the associated ongoing pandemic …
virus, the cause of coronavirus disease (COVID-19) and the associated ongoing pandemic …
[HTML][HTML] COVID-19 a triggering factor of autoimmune and multi-inflammatory diseases
EK Sher, A Ćosović, A Džidić-Krivić, EK Farhat, E Pinjić… - Life sciences, 2023 - Elsevier
SARS-Cov-2 virus has attracted a lot of attention globally, due to the autoimmune and
inflammatory processes that were observed during the development of Covid-19 disease …
inflammatory processes that were observed during the development of Covid-19 disease …
SARS-CoV-2 infection drives an inflammatory response in human adipose tissue through infection of adipocytes and macrophages
GJ Martínez-Colón, K Ratnasiri, H Chen… - Science Translational …, 2022 - science.org
Obesity, characterized by chronic low-grade inflammation of the adipose tissue, is
associated with adverse coronavirus disease 2019 (COVID-19) outcomes, yet the …
associated with adverse coronavirus disease 2019 (COVID-19) outcomes, yet the …
[HTML][HTML] Immune-based prediction of COVID-19 severity and chronicity decoded using machine learning
BK Patterson, J Guevara-Coto, R Yogendra… - Frontiers in …, 2021 - frontiersin.org
Expression of CCR5 and its cognate ligands have been implicated in COVID-19
pathogenesis, consequently therapeutics directed against CCR5 are being investigated …
pathogenesis, consequently therapeutics directed against CCR5 are being investigated …
[HTML][HTML] Impact of age and sex on COVID-19 severity assessed from radiologic and clinical findings
Y Statsenko, F Al Zahmi, T Habuza… - Frontiers in cellular …, 2022 - frontiersin.org
Background Data on the epidemiological characteristics and clinical features of COVID-19 in
patients of different ages and sex are limited. Existing studies have mainly focused on the …
patients of different ages and sex are limited. Existing studies have mainly focused on the …
[HTML][HTML] SARS-CoV-2 B. 1.1. 7 (alpha) and B. 1.351 (beta) variants induce pathogenic patterns in K18-hACE2 transgenic mice distinct from early strains
P Radvak, HJ Kwon, M Kosikova… - Nature …, 2021 - nature.com
SARS-CoV-2 variants of concern (VOC) B. 1.1. 7 (alpha) and B. 1.351 (beta) show increased
transmissibility and enhanced antibody neutralization resistance. Here we demonstrate in …
transmissibility and enhanced antibody neutralization resistance. Here we demonstrate in …
[HTML][HTML] IL-13 is a driver of COVID-19 severity
AN Donlan, TE Sutherland, C Marie, S Preissner… - JCI insight, 2021 - ncbi.nlm.nih.gov
Immune dysregulation is characteristic of the more severe stages of SARS-CoV-2 infection.
Understanding the mechanisms by which the immune system contributes to COVID-19 …
Understanding the mechanisms by which the immune system contributes to COVID-19 …
Small-molecule inhibitors of the coronavirus spike: ACE2 protein–protein interaction as blockers of viral attachment and entry for SARS-CoV-2
D Bojadzic, O Alcazar, J Chen, ST Chuang… - ACS infectious …, 2021 - ACS Publications
Inhibitors of the protein–protein interaction (PPI) between the SARS-CoV-2 spike protein
and human ACE2 (hACE2), which acts as a ligand–receptor pair that initiates the viral …
and human ACE2 (hACE2), which acts as a ligand–receptor pair that initiates the viral …
[HTML][HTML] COVID-19 generates hyaluronan fragments that directly induce endothelial barrier dysfunction
KA Queisser, RA Mellema, EA Middleton, I Portier… - JCI insight, 2021 - ncbi.nlm.nih.gov
Vascular injury has emerged as a complication contributing to morbidity in coronavirus
disease 2019 (COVID-19). The glycosaminoglycan hyaluronan (HA) is a major component …
disease 2019 (COVID-19). The glycosaminoglycan hyaluronan (HA) is a major component …
Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19
ED Hottz, R Martins-Gonçalves, L Palhinha… - Blood …, 2022 - ashpublications.org
Accumulating evidence into the pathogenesis of COVID-19 highlights a hypercoagulability
state with high risk of life-threatening thromboembolic complications. However, the …
state with high risk of life-threatening thromboembolic complications. However, the …