Bone fractures are the most common traumatic injuries in humans. The repair of bone
fractures is a regenerative process that recapitulates many of the biological events of …

In modern medicine, bone and dental loss and defects are common and widespread
morbidities, for which regenerative therapy has shown great promise. Mesenchymal stem …

To investigate roles for bone marrow adipocyte (BMAd) lipolysis in bone homeostasis, we
created a BMAd-specific Cre mouse model in which we knocked out adipose triglyceride …

Recent studies have determined that the nervous system can sense and respond to signals
from skeletal tissue, a process known as skeletal interoception, which is crucial for …

Inorganic polyphosphates (polyP) consist of linear chains of orthophosphate residues,
linked by high-energy phosphoanhydride bonds. They are evolutionarily old biopolymers …

Reproductive hormones play a crucial role in the growth and maintenance of the
mammalian skeleton. Indeed, the biological significance for this hormonal regulation of …

Much of the mammalian skeleton originates from a cartilage template eventually replaced by
bone via endochondral ossification. Despite much knowledge about growth factors and …

Osteocytes, the most abundant bone cell type, are derived from osteoblasts through a
process in which they are embedded in an osteoid. We previously showed that nutrient …

During bone development, homeostasis and repair, a dense vascular system provides
oxygen and nutrients to highly anabolic skeletal cells. Characteristic for the vascular system …

Angiogenesis and osteogenesis are coupled. However, the cellular and molecular
regulation of these processes remains to be further investigated. Both tissues have recently …