The how and why of lncRNA function: an innate immune perspective

EK Robinson, S Covarrubias, S Carpenter - Biochimica et Biophysica Acta …, 2020 - Elsevier
Next-generation sequencing has provided a more complete picture of the composition of the
human transcriptome indicating that much of the “blueprint” is a vastness of poorly …

[HTML][HTML] Genomic selection in aquaculture: application, limitations and opportunities with special reference to marine shrimp and pearl oysters

KR Zenger, MS Khatkar, DB Jones… - Frontiers in …, 2019 - frontiersin.org
Within aquaculture industries, selection based on genomic information (genomic selection)
has the profound potential to change genetic improvement programs and production …

[图书][B] Resisting AI: an anti-fascist approach to artificial intelligence

D McQuillan - 2022 - books.google.com
Artificial Intelligence (AI) is everywhere, yet it causes damage to society in ways that can't be
fixed. Instead of helping to address our current crises, AI causes divisions that limit people's …

Unravelling the human genome–phenome relationship using phenome-wide association studies

WS Bush, MT Oetjens, DC Crawford - Nature Reviews Genetics, 2016 - nature.com
Advances in genotyping technology have, over the past decade, enabled the focused
search for common genetic variation associated with human diseases and traits. With the …

How far from the SNP may the causative genes be?

A Brodie, JR Azaria, Y Ofran - Nucleic acids research, 2016 - academic.oup.com
While GWAS identify many disease-associated SNPs, using them to decipher disease
mechanisms is hindered by the difficulty in mapping SNPs to genes. Most SNPs are in non …

[PDF][PDF] Association of polygenic risk scores for multiple cancers in a phenome-wide study: results from the Michigan Genomics Initiative

LG Fritsche, SB Gruber, Z Wu, EM Schmidt… - The American Journal of …, 2018 - cell.com
Health systems are stewards of patient electronic health record (EHR) data with
extraordinarily rich depth and breadth, reflecting thousands of diagnoses and exposures …

The contribution of genetic variants to disease depends on the ruler

JS Witte, PM Visscher, NR Wray - Nature Reviews Genetics, 2014 - nature.com
Our understanding of the genetic basis of disease has evolved from descriptions of overall
heritability or familiality to the identification of large numbers of risk loci. One can quantify the …

[HTML][HTML] Stitching together multiple data dimensions reveals interacting metabolomic and transcriptomic networks that modulate cell regulation

J Zhu, P Sova, Q Xu, KM Dombek, EY Xu, H Vu… - PLoS …, 2012 - journals.plos.org
Cells employ multiple levels of regulation, including transcriptional and translational
regulation, that drive core biological processes and enable cells to respond to genetic and …

[HTML][HTML] Next generation genome-wide association tool: design and coverage of a high-throughput European-optimized SNP array

TJ Hoffmann, MN Kvale, SE Hesselson, Y Zhan… - Genomics, 2011 - Elsevier
The success of genome-wide association studies has paralleled the development of efficient
genotyping technologies. We describe the development of a next-generation microarray …

The heritability of ocular traits

PG Sanfilippo, AW Hewitt, CJ Hammond… - Survey of …, 2010 - Elsevier
Heritability is the proportion of phenotypic variation in a population that is attributable to
genetic variation among individuals. Many ophthalmic disorders and biometric traits are …