[HTML][HTML] Targeting apoptosis pathways in cancer and perspectives with natural compounds from mother nature

FM Millimouno, J Dong, L Yang, J Li, X Li - Cancer prevention research, 2014 - AACR
Although the incidences are increasing day after day, scientists and researchers taken
individually or by research group are trying to fight against cancer by several ways and also …

[HTML][HTML] Parthenolide as cooperating agent for anti-cancer treatment of various malignancies

M Sztiller-Sikorska, M Czyz - Pharmaceuticals, 2020 - mdpi.com
Primary and acquired resistance of cancer to therapy is often associated with activation of
nuclear factor kappa B (NF-κB). Parthenolide (PN) has been shown to inhibit NF-κB …

Sesquiterpene lactones as drugs with multiple targets in cancer treatment: focus on parthenolide

MRO Kreuger, S Grootjans, MW Biavatti… - Anti-cancer …, 2012 - journals.lww.com
Sesquiterpene lactones (SLs) constitute a large and diverse group of biologically active
plant compounds that possess anti-inflammatory and antitumor activity. The subclass …

The effect of ultraviolet radiation on the accumulation of medicinal compounds in plants

WJ Zhang, LO Björn - Fitoterapia, 2009 - Elsevier
A review is given of how the production by plants of compounds useful as medicines or raw
materials for manufacture of medicines is influenced by ultraviolet radiation, particularly by …

Sesquiterpene lactones: adverse health effects and toxicity mechanisms

MHR Amorim, RM Gil da Costa, C Lopes… - Critical reviews in …, 2013 - Taylor & Francis
Sesquiterpene lactones (STLs) present a wide range of biological activities, mostly based on
their alkylating capabilities, which underlie their therapeutic potential. These compounds are …

[HTML][HTML] Potential anti-cancer activities and mechanisms of costunolide and dehydrocostuslactone

X Lin, Z Peng, C Su - International journal of molecular sciences, 2015 - mdpi.com
Costunolide (CE) and dehydrocostuslactone (DE) are derived from many species of
medicinal plants, such as Saussurea lappa Decne and Laurus nobilis L. They have been …

[HTML][HTML] Induction of apoptosis by costunolide in bladder cancer cells is mediated through ROS generation and mitochondrial dysfunction

A Rasul, R Bao, M Malhi, B Zhao, I Tsuji, J Li, X Li - Molecules, 2013 - mdpi.com
Despite the availability of several therapeutic options, a safer and more effective modality is
urgently needed for treatment of bladder cancer. Costunolide, a member of sesquiterpene …

Costunolide ameliorates intestinal dysfunction and depressive behaviour in mice with stress-induced irritable bowel syndrome via colonic mast cell activation and …

X Li, Q Liu, J Yu, R Zhang, T Sun, W Jiang, N Hu… - Food & Function, 2021 - pubs.rsc.org
Irritable bowel syndrome (IBS) is a common chronic functional bowel disease, associated
with a high risk of depression and anxiety. The brain–gut axis plays an important role in the …

[HTML][HTML] Parthenolide and its soluble analogues: multitasking compounds with antitumor properties

D Carlisi, M Lauricella, A D'Anneo, A De Blasio… - Biomedicines, 2022 - mdpi.com
Due to its chemical properties and multiple molecular effects on different tumor cell types,
the sesquiterpene lactone parthenolide (PN) can be considered an effective drug with …

Costunolide: A novel anti-cancer sesquiterpene lactone

A Rasul, S Parveen, T Ma - Bangladesh Journal of Pharmacology, 2012 - banglajol.info
Currently an ample interest is found among oncologists to explore anticancer compounds
from herbs. Sesquiterpene lactones have accredited significant attention in pharmacological …